Figure 1

Effects of Imatinib on time course of proteinuria (A) and systolic blood pressure after 10 and 20 weeks (B) in chronic anti-thy1 glomerulosclerosis (cGS). Administration of Imatinib was started 7 days after injection of anti-thy1 antibody into uni-nephrectomized rats (cGS + Imatinib). Nonnephritic animals with (1-K Control) and without uninephrectomy (2-K Control) received an injection with similar volumes of PBS. Blood pressure was measured in conscious animals using a tail cuff method. Urine was collected for 24 h at the indicated times, using metabolic cages. (*p < 0.05 and **p < 0.01 vs. cGS).