Figure 5
Effects of Imatinib on tubulointerstitial (A) and glomerular (B) myofibroblast differentiation 20 weeks after induction of chronic anti-thy1 glomerulosclerosis (cGS). Administration of Imatinib was started 7 days after injection of anti-thy1 antibody into uni-nephrectomized rats (cGS + Imatinib). Nonnephritic animals with (1-K Control) and without uninephrectomy (2-K Control) received an injection with similar volumes of PBS. Analysis was performed using a primary α-SMA-antibody for myofibroblast. Data are expressed as percentage of α-SMA-positive expression per cortical section observed at ×200 magnification and per glomerular cross section (***p < 0.001 vs. cGS).