Figure 6

Effects of Imatinib on tubulointerstitial and glomerular macrophage infiltration (A, B) and cell proliferation (C, D) 20 weeks after induction of chronic anti-thy1 glomerulosclerosis (cGS). Administration of Imatinib was started 7 days after injection of anti-thy1 antibody into uni-nephrectomized rats (cGS + Imatinib). Nonnephritic animals with (1-K Control) and without uninephrectomy (2-K Control) received an injection with similar volumes of PBS. Analysis was performed using a primary ED1-antibody for macrophages and a primary PCNA-antibody for proliferating cells. Data are expressed as cells per cortical section observed at ×200 magnification and per glomerular cross section (*p < 0.05 and **p < 0.01 vs. cGS).