Skip to main content

Table 2 Effects of Imatinib on glomerular matrix protein expression 20 weeks after induction of chronic anti-thy1 glomerulosclerosis (cGS)

From: Tyrosine kinases inhibition by Imatinib slows progression in chronic anti-thy1 glomerulosclerosis of the rat

Group/parameter

Glomerular matrix score (%)

Glomerular TGF-βprotein expression (pg/ml)

Glomerular fibronectin protein expression (pg/ml)

2-K Control

21 ± 4

22 ± 22

2600 ± 182

1-K Control

24 ± 4

28 ± 30

2695 ± 356

cGS

56 ± 17**

101 ± 76**

5625 ± 1570**

cGS + Imatinib

49 ± 17

84 ± 52

4879 ± 1387

  1. Shown are glomerular matrix accumulation and protein expression of TGF-β1 and fibronectin. Administration of Imatinib was started 7 days after injection of anti-thy1 antibody into uni-nephrectomized rats (cGS + Imatinib). Nonnephritic animals with (1-K Control) and without uninephrectomy (2-K Control) received an injection with similar volumes of PBS. Matrix expansion was scored on PAS-stained slides (%). Glomeruli were harvested from individual animals and cultured at a density of 2000 per mL for 48 h. (**p < 0.01 vs. Controls).
Back to article page

BMC Nephrology

ISSN: 1471-2369

Contact us