From: Association of frailty and physical function in patients with non-dialysis CKD: a systematic review
First author, year | Population | na | Association | Physical measurement | Observer or self-reporting | Kidney function endpoint | Endpoint definition |
---|---|---|---|---|---|---|---|
CKD and frailty associated with outcome | Â | ||||||
Wilhelm-Leen [14] | age ≥20 3–5 frailty domains measured NHANES III | 10,256 | Frailty and CKD linked to mortality | Modified Fried Frailty Criteria | Both | Chronic Kidney Disease Stage 5 | CKD Stage 5 definition: eGFR <45 mL /min/1.73 m2 |
Roshanravan [15] | age ≥18 CKD Stages 1–4 not requiring dialysis | 336 | Frailty associated with lower eGFR and higher risk of death or dialysis therapy | Modified Fried Frailty Criteria | Both | Chronic Kidney Disease | CKD definition: eGFR <90 mL /min/1.73 m2 OR albuminuriab |
CKD and frailty associated | Â | ||||||
Odden [17] | previous cardiac event or disease | 954 | CKD associated with physical limitation and reduced exercise capacity | Exercise and Functional Capacity | Both | Chronic Kidney Disease Stage 3 or higher | CKD Stage 3 definition: Creatinine clearance <60 ml/min |
Shlipak [18] | Medicare eligibility age > 65 non-institutionalized | 5,808 | CRI associated with frailty in community dwelling elder adults | Fried Frailty Criteria | Both | Chronic Renal Insufficiency | CRI definition: Male = serum creatinine >1.5 mg/dL, Female = serum creatinine >1.3 mg/dL |
Fried [4] | Medicare eligibility age 70–79 no existing functional limitation | 2,135 | CKD associated with development of impaired physical function | Functional Limitation | Self | Kidney Function Quartile | Cystatin C input to MDRD. Secondary analysis grouped patients as eGFR <60 mL /min/1.73 m2 vs other |
Bowling [19] | Community-dwelling Medicare beneficiaries age ≥65 | 357 | CKD associated with functional decline | IADLs and BADLs | Self | Chronic Kidney Disease Stage 3 or higher | CKD definition: eGFR <60 mL /min/1.73 m2 |
Lattanzio [16] | Older Hospitalized Patients | 486 | Reduced kidney function associated with poor physical performance | Short Physical Performance Battery | Observer | Chronic Kidney Disease Stage 3 or higher | CKD definition: eGFR <60 mL /min/1.73 m2 |