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Table 2 Associations between renal factors and high sensitivity troponin t

From: Predictors of high sensitivity cardiac troponin T in chronic kidney disease patients: a cross-sectional study in the chronic renal insufficiency cohort (CRIC)

   Unadjusted Model 1 Model 2
  N* Tobit ratio (95% CI) P Tobit ratio (95% CI) P Tobit ratio (95% CI) P
eGFRcys* (ml/min/1.73 m 2 )        
≥ 60 757 Reference - Reference   Reference -
45-59 684 2.11 (1.86-2.41) < 0.001 1.51 (1.35-1.69) < 0.001 1.50 (1.34-1.67) < 0.001
30-44 705 3.02 (2.66-3.44) < 0.001 1.97 (1.74-2.22) < 0.001 1.96 (1.74-2.21) < 0.001
< 30 311 5.27 (4.47-6.21) < 0.001 2.90 (2.47-3.41) < 0.001 2.83 (2.41-3.33) < 0.001
ACR (μg/mg) †        
< 30 1115 Reference - Reference   Reference -
30-299 582 1.58 (1.39-1.80) < 0.001 1.08 (0.98-1.20) 0.130 1.06 (0.96-1.19) 0.214
300-999 338 1.94 (1.66-2.28) < 0.001 1.09 (0.96-1.25) 0.191 1.08 (0.95-1.23) 0.238
≥ 1000 325 3.61 (3.08-4.23) < 0.001 1.56 (1.35-1.81) < 0.001 1.53 (1.32-1.77) < 0.001
Phosphate (mg/dL)        
< 3 265 Reference - Reference   Reference -
3-3.9 1427 1.08 (0.90-1.28) 0.419 1.02 (0.90-1.17) 0.739 1.02 (0.90-1.17) 0.711
4-4.9 646 1.59 (1.31-1.93) < 0.001 1.06 (0.91-1.23) 0.445 1.06 (0.92-1.24) 0.412
≥ 5 81 3.51 (2.52-4.90) < 0.001 1.35 (1.04-1.76) 0.023 1.39 (1.08-1.81) 0.012
FGF-23 ‡        
Quartile I 606 Reference   Reference   Reference  
Quartile II 606 1.45 (1.25-1.68) < 0.001 1.07 (0.96-1.20) 0.230 1.08 (0.96-1.21) 0.206
Quartile III 606 2.11 (1.82-2.45) < 0.001 1.20 (1.06-1.35) 0.004 1.17 (1.04-1.33) 0.011
Quartile IV 606 2.62 (2.26-3.04) < 0.001 1.22 (1.06-1.40) 0.004 1.17 (1.02-1.34) 0.021
  1. *N’s are # observations among participants with TnT measurements, with 7 observation excluded.
  2. Model 1 adjusted for: age (per SD), female, race, diabetes, SBP categories, albumin (per SD), eGFR_CysC, ACR, and phosphate and FGF-23. Model 2 adjusted for: Model 1 + LV mass, ejection fraction.
  3. eGFRcys=cystatin-based estimated glomerular filtration rate. † albumin to creatinine ratio. ‡ fibroblast growth factor 23.