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Table 2 Associations between renal factors and high sensitivity troponin t

From: Predictors of high sensitivity cardiac troponin T in chronic kidney disease patients: a cross-sectional study in the chronic renal insufficiency cohort (CRIC)

  

Unadjusted

Model 1

Model 2

 

N*

Tobit ratio (95% CI)

P

Tobit ratio (95% CI)

P

Tobit ratio (95% CI)

P

eGFRcys* (ml/min/1.73 m 2 )

       

≥ 60

757

Reference

-

Reference

 

Reference

-

45-59

684

2.11 (1.86-2.41)

< 0.001

1.51 (1.35-1.69)

< 0.001

1.50 (1.34-1.67)

< 0.001

30-44

705

3.02 (2.66-3.44)

< 0.001

1.97 (1.74-2.22)

< 0.001

1.96 (1.74-2.21)

< 0.001

< 30

311

5.27 (4.47-6.21)

< 0.001

2.90 (2.47-3.41)

< 0.001

2.83 (2.41-3.33)

< 0.001

ACR (μg/mg) †

       

< 30

1115

Reference

-

Reference

 

Reference

-

30-299

582

1.58 (1.39-1.80)

< 0.001

1.08 (0.98-1.20)

0.130

1.06 (0.96-1.19)

0.214

300-999

338

1.94 (1.66-2.28)

< 0.001

1.09 (0.96-1.25)

0.191

1.08 (0.95-1.23)

0.238

≥ 1000

325

3.61 (3.08-4.23)

< 0.001

1.56 (1.35-1.81)

< 0.001

1.53 (1.32-1.77)

< 0.001

Phosphate (mg/dL)

       

< 3

265

Reference

-

Reference

 

Reference

-

3-3.9

1427

1.08 (0.90-1.28)

0.419

1.02 (0.90-1.17)

0.739

1.02 (0.90-1.17)

0.711

4-4.9

646

1.59 (1.31-1.93)

< 0.001

1.06 (0.91-1.23)

0.445

1.06 (0.92-1.24)

0.412

≥ 5

81

3.51 (2.52-4.90)

< 0.001

1.35 (1.04-1.76)

0.023

1.39 (1.08-1.81)

0.012

FGF-23 ‡

       

Quartile I

606

Reference

 

Reference

 

Reference

 

Quartile II

606

1.45 (1.25-1.68)

< 0.001

1.07 (0.96-1.20)

0.230

1.08 (0.96-1.21)

0.206

Quartile III

606

2.11 (1.82-2.45)

< 0.001

1.20 (1.06-1.35)

0.004

1.17 (1.04-1.33)

0.011

Quartile IV

606

2.62 (2.26-3.04)

< 0.001

1.22 (1.06-1.40)

0.004

1.17 (1.02-1.34)

0.021

  1. *N’s are # observations among participants with TnT measurements, with 7 observation excluded.
  2. Model 1 adjusted for: age (per SD), female, race, diabetes, SBP categories, albumin (per SD), eGFR_CysC, ACR, and phosphate and FGF-23. Model 2 adjusted for: Model 1 + LV mass, ejection fraction.
  3. eGFRcys=cystatin-based estimated glomerular filtration rate. † albumin to creatinine ratio. ‡ fibroblast growth factor 23.