Table 1 First tier IRI gene candidates
Gene | Symbol | χ 2P value | Wscore | PubMatrix search terms | ||
|---|---|---|---|---|---|---|
Kidney injury | Kidney ischemia reperfusion injury | Kidney transplantation | ||||
Lipocalin 2 | LCN2 | 2.36E-11 | 33.3 | 314 | 38 | 57 |
TYRO tyrosine kinase binding protein | TYROBP | 5.54E-08 | 22.3 | 2 | 1 | 1 |
Annexin A1 | ANXA1 | 4.52E-14 | 27 | 3 | 3 | 1 |
Chemokine (C-C motif) ligand 2 | CCL2 | 3.97E-11 | 36 | 313 | 56 | 96 |
Heme oxygenase (decycling) 1 | HMOX1 | 3.97E-11 | 27 | 291 | 100 | 110 |
Clusterin | CLU | 3.97E-11 | 25.5 | 27 | 1 | 11 |
Early growth response 2 | EGR2 | 1.43E-10 | 19 | 0 | 0 | 0 |
Cyclin-dependent kinase inhibitor 1A | CDKN1A | 2.34E-10 | 26 | 83 | 16 | 28 |
Activating transcription factor 3 | ATF3 | 1.38E-09 | 29 | 5 | 5 | 1 |
Chemokine (C-X-C motif) ligand 1 | CXCL1 | 1.38E-09 | 25 | 32 | 18 | 11 |
ADAM metallopeptidase with TS1 | ADAMTS1 | 1.75E-09 | 29 | 2 | 1 | 1 |
RAS, dexamethasone-induced 1 | RASD1 | 5.33E-09 | 18 | 1 | 1 | 1 |
TIMP metallopeptidase inhibitor 1 | TIMP1 | 8.11E-09 | 31 | 162 | 57 | 163 |
TNF receptor superfamily, member 12A | TNFRSF12A | 9.88E-09 | 32.5 | 9 | 1 | 2 |
Jun proto-oncogene | JUN | 5.52E-08 | 23 | 134 | 37 | 36 |
Filamin A, alpha | FLNA | 5.52E-08 | 19 | 0 | 0 | 0 |
Intercellular adhesion molecule 1 | ICAM1 | 5.52E-08 | 18 | 352 | 131 | 244 |
Secreted phosphoprotein 1 | SPP1 | 5.54E-08 | 24 | 95 | 7 | 22 |
Lectin, galactoside-binding, soluble, 3 | LGALS3 | 5.54E-08 | 21 | 11 | 4 | 3 |
Baculoviral IAP repeat-containing 3 | BIRC3 | 1.66E-06 | 14 | 1 | 0 | 1 |