Table 1 Clinical characteristics of the patients at CRRT start
Variable | Protocol A (n = 20) | Protocol B (n = 20) | P value |
|---|---|---|---|
Female gender | 7/20 (35%) | 4/20 (20%) | 0.480 |
Age, years | 72 (69–77) | 70 (59–73) | 0.073 |
Body weight, kg | 72 (67–79) | 70 (66–80) | 0.715 |
Oliguric AKI § | 90% | 75% | 0.407 |
Mean arterial pressure, mmHg | 70 (70–80) | 70 (62–80) | 0.399 |
Use of vasopressors or inotropes | 75% | 85% | 0.695 |
Mechanical ventilation | 85% | 90% | 0.633 |
Artificial nutrition | 95% | 100% | 0.311 |
APACHE II score | 32 (29–35) | 32 (27–35) | 0.307 |
SOFA score | 15 (12–16) | 13 (9–14) | 0.056 |
SOFA cardio-vascular score | 3 (2–3) | 3 (2–3) | 0.130 |
Serum creatinine, mg/dl | 2.10 (1.75–3.00) | 2.25 (1.75–2.85) | 0.469 |
Blood urea nitrogen, mg/dl | 40.5 (26.9–62.0) | 40.5 (29.0–55.2) | 0.978 |
Hemoglobin, g/dl | 10.9 (9.9–11.2) | 10.0 (8.8–10.9) | 0.084 |
Hematocrit,% | 32.1 (31.2–33.4) | 31.6 (27.5–34.5) | 0.419 |
White blood cells, ×103/μl | 11.0 (8.2–15.9) | 12.4 (11.0–16.5) | 0.664 |
Platelet count, ×103/μl | 93 (76–177) | 161 (98–254) | 0.043 |
Antithrombin III activity,% | 70 (63–78) | 61 (49–78) | 0.250 |
APTT Ratio | 1.4 (1.3–1.9) | 1.6 (1.4–2) | 0.358 |
Sodium, mmol/l | 139 (134–140) | 139 (137–143) | 0.110 |
Potassium, mmol/l | 4.3 (4.0–4.8) | 4.2 (4.1–4.8) | 0.762 |
Total Calcium, mmol/l | 2.16 (1.95–2.30) | 2.03 (1.93–2.19) | 0.166 |
Phosphorus, mmol/l | 1.40 (1.07–1.58) | 1.38 (1.16–1.70) | 0.897 |
Magnesium, mmol/l | 0.85 (0.75–0.93) | 0.78 (0.74–0.97) | 0.572 |
pH, units | 7.38 (7.35–7.41) | 7.40 (7.38–7.43) | 0.324 |
Bicarbonate, mmol/l | 21.8 (21.0–22.6) | 22.2 (21.0–24.2) | 0.535 |
Base Excess | -3.5 (-4.0 to -2.0) | -1.0 (-4.0 to 1.0) | 0.316 |
pCO2, mmHg | 38 (36–42) | 37 (33–40) | 0.992 |
Lactate, mmol/l | 1.4 (1.0–3.0) | 1.4 (1.2–2.4) | 0.879 |
Bilirubin, mg/dl | 0.89 (0.62–1.45) | 0.73 (0.46–1.37) | 0.376 |
Aspartate aminotransferase, IU/l | 89 (29–608) | 97 (49–376) | 0.800 |
Alanine aminotransferase, IU/l | 37 (12–325) | 26 (18–75) | 0.970 |
Albumin, g/dl | 2.6 (2.4–2.8) | 2.45 (2.2–2.9) | 0.820 |
Heart surgery: | Overall | ||
Coronary artery bypass grafting | 25% | 35% | 30% |
Coronary artery bypass grafting + valvular surgery | 40% | 15% | 27.5% |
Valvular surgery | 25% | 20% | 22.5% |
Ascending aorta replacement | 10% | 30% | 20% |