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Table 2 Initial RCA-CRRT settings

From: Continuous venovenous hemodiafiltration with a low citrate dose regional anticoagulation protocol and a phosphate-containing solution: effects on acid–base status and phosphate supplementation needs

RCA-CRRT settings Protocol A Protocol B P-value
Prescribed dialysis dose§, ml/kg/h 28.25 (26.69–29.66) 26.67 (25.69–28.88) 0.333
Blood flow rate, ml/min 130 (130–140) 140 (140–140) 0.083
Pre-dilution citrate solution flow rate, l/h 1.56 (1.50–1.68) 1.00 (1.00–1.00) <0.001
Pre-dilution,% 16.67 (16.58–16.67) 10.64 (10.64–10.64) <0.001
Post-dilution replacement fluid flow rate, l/h 0.80 (0.80–0.95) 0.60 (0.55–0.80) <0.001
Dialysate flow rate, l/h N/A 0.50 (0.50–0.50) -
Filtration Fraction,% 38.4 (34.5–40.3) 27.0 (25.7–28.8) <0.001
10% Calcium chloride infusion rate, mmol/h 2.00 (1.60–2.10) 1.90 (1.36–2.28) 0.344
Citrate infusion rate, mmol/h 18.70 (18.00–20.15) 18.00 (18.00–18.00) 0.051
Estimated citrate load, mmol/h 12.34 (11.74–13.92) 12.35 (12.05–12.65) 0.471
Estimated citrate dose, mmol/l 2.84 (2.74–2.91) 2.83 (2.76–2.95) 0.618
  1. Data are expressed as median (IQR). § Corrected for pre-dilution.