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Table 4 Laboratory variables and supplementation needs during RCA-CRRT

From: Continuous venovenous hemodiafiltration with a low citrate dose regional anticoagulation protocol and a phosphate-containing solution: effects on acid–base status and phosphate supplementation needs

Variable Protocol A (n = 20) Protocol B (n = 20) P value
Systemic Ca2+, mmol/l 1.16 (1.10–1.23) 1.16 (1.11–1.21) 0.995
Total Calcium, mmol/l 2.33 (2.20–2.50) 2.33 (2.21–2.45) 0.474
Calcium Ratio 1.95 (1.84–2.09) 1.98 (1.89–2.09) 0.296
Circuit Ca2+, mmol/l 0.37 (0.32–0.40) 0.42 (0.36–0.47) <0.001
Sodium, mmol/l 134 (133–136) 134 (132–135) 0.213
Potassium, mmol/l 4.2 (4.0–4.3) 4.2 (4.0–4.4) 0.159
Phosphate, mmol/l 0.70 (0.50–1.00) 1.20 (0.97–1.45) <0.001
Magnesium, mmol/l 0.78 (0.58–0.95) 0.79 (0.73–0.84) <0.001
pH, units 7.40 (7.36–7.44) 7.43 (7.40–7.46) <0.001
Bicarbonate, mmol/l 22.1 (20.9–23.5) 25.3 (23.8–26.6) <0.001
Base Excess -3.1 (-4.6 to -1.1) 0.9 (-0.8 to 2.4) <0.001
pCO2, mmHg 35 (32–41) 38 (35–40) 0.527
Apparent strong ion difference (AppSID), mEq/l 37.6 (36.1–39.4) 39.1 (37.9–40.2) <0.001
Effective strong ion difference (EffSID), mEq/l 32.0 (30.6–33.1) 34.3 (32.8–35.9) <0.001
Strong ion gap (SIG), mEq/l 5.8 (3.5–7.7) 4.5 (3.1–6.9) 0.585
Lactate, mmol/l 1.2 (0.9–1.6) 1.1 (0.8–1.4) <0.001
Platelet count, ×103/μl 90 (53–156) 187 (121–261) <0.001
Antithrombin III activity,% 72 (62–81) 75 (63–89) 0.078
aPTT Ratio 1.4 (1.3–1.6) 1.4 (1.2–1.7) 0.575
Supplementation needs    
CaCl2 infusion, mmol/h 2.18 (1.90–2.45) 2.24 (1.97–2.58) 0.800
KCl infusion, mmol/h 5 (3–7) 2 (0–4) <0.001
Magnesium Sulphate, g/day 3 (2–3) 3 (3–3) <0.001
Need for bicarbonate infusion, n (%) 18/20 (90%) 0/20 (0%) <0.001
   Infusion rate, mmol/h 6 ± 6.4 No supplementation
Need for phosphate supplementation, n (%) 20/20 (100%) 6/20 (30%) <0.001
   g of phosphorus/day 3.39 ± 2.45 0.52 ± 1.53
  1. Data are expressed as median (IQR) or mean ± SD or percentage.