Skip to main content

Table 2 Efficacy of long-term (8 week) treatment with mozavaptan or etanercept in pck rats a

From: TNF-α blockade is ineffective in animal models of established polycystic kidney disease

Treatment

Kidney weight (% of bw)

Cyst number (per field)

BUN (mg/dL)

CREA (mg/dL)

Water consumptiond(mL/rat/day0029)

Vehicle

1.05 ± 0.023

9.2 ± 0.71

14.9 ± 0.51

0.63 ± 0.05

42.96 ± 1.96

Mozavaptan (0.1%)

1.12 ± 0.04

12.1 ± 1.4

16.2 ± 0.39

0.71 ± 0.03b

63.88 ± 0.56c

Etanercept (5 mg/kg)

1.16 ± 0.036

12 ± 1.3

16.4 ± 0.4

0.71 ± 0.06b

38.95 ± 1.40

  1. aData shown are group average ± SEM, N=10.
  2. bComparison between vehicle and treatment group(s), p < 0.05.
  3. cComparison between vehicle and treatment group(s), p < 0.001.
  4. dWater consumption measured over final week of treatment.
Back to article page

BMC Nephrology

ISSN: 1471-2369

Contact us