Table 2 Outcome Ascertainment for INSIGHT

Clinical

Remission: Urine protein/creatinine < 0.2 or Albustik negative or trace for 3 consecutive days

Relapse: After remission, an increase in the first morning urine protein/creatinine ≥2 for 3 of 5 consecutive days

Frequently relapsing NS: 4 or more relapses within 1 year OR 2 or more relapses within 6 months

Steroid dependant NS: Relapse during steroid taper or within 14 days of steroid discontinuation

Steroid resistant: Inability to induce remission within 28 days of steroid therapy

Laboratory

Urine protein/creatinine: Abnormal if > 250 mg/mmol

Urine albumin/creatinine: Abnormal if > 30 mg/mol

Creatinine based eGFR: eGFR by modified Schwartz (ml/min/1.73 m²) = k x height/serum creatinine

CKD/ESRD: eGFR < 60 ml/min/1.73 m² (or dialysis)