A comparison of CKD-EPI estimated glomerular filtration rate and measured creatinine clearance in recently admitted critically ill patients with normal plasma creatinine concentrations

Table 2 Comparison, correlation, bias and precision between measured 8-hr CL _CR and mathematical estimates in all patients, and each diagnostic sub-group

	Mean (SD)	r ( P-value)	Bias +/− precision
All patients (n = 110)
CL_CR, ml/min/1.73 m²	125 (45.1)
175 eGFR, ml/min/1.73 m²	110 (41.6)*	0.600 (<0.001)	15.6 +/− 38.9
CG CL_CR, ml/min/1.73 m²	119 (41.7)	0.638 (<0.001)	6.23 +/− 37.1
CKD-EPI eGFR, ml/min/1.73 m²	101 (23.7)*	0.720 (<0.001)	24.4 +/− 32.5
Elective admissions (n = 15)
CL_CR, ml/min/1.73 m²	118 (27.2)
175 eGFR, ml/min/1.73 m²	115 (51.2)	0.325 (0.237)	2.77 +/− 49.5
CG CL_CR, ml/min/1.73 m²	119 (44.1)	0.531 (0.042)	−1.04 +/− 37.5
CKD-EPI eGFR, ml/min/1.73 m²	101 (20.0)**	0.488 (0.065)	17.2 +/− 24.7
Emergency admission (n = 33)
CL_CR, ml/min/1.73 m²	113 (50.0)
175 eGFR, ml/min/1.73 m²	114 (47.9)	0.624 (<0.001)	−0.77 +/− 42.5
CG CL_CR, ml/min/1.73 m²	123 (49.1)	0.599 (<0.001)	−10.4 +/− 44.3
CKD-EPI eGFR, ml/min/1.73 m²	99 (27.6)**	0.692 (<0.001)	13.8 +/− 36.8
Surgical emergency admission (n = 37)
CL_CR, ml/min/1.73 m²	125 (46.4)
175 eGFR, ml/min/1.73 m²	101 (37.2)*	0.741 (<0.001)	23.7 +/− 31.3
CG CL_CR, ml/min/1.73 m²	108 (37.5)**	0.753 (<0.001)	16.4 +/− 30.6
CKD-EPI eGFR, ml/min/1.73 m²	95 (23.7)*	0.779 (<0.001)	29.5 +/− 31.6
Trauma admission (n = 25)
CL_CR, ml/min/1.73 m²	146 (39.5)
175 eGFR, ml/min/1.73 m²	114 (32.0)*	0.745 (<0.001)	32.7 +/− 26.5
CG CL_CR, ml/min/1.73 m²	129 (33.8)**	0.757 (<0.001)	17.4 +/− 26.1
CKD-EPI eGFR, ml/min/1.73 m²	111 (17.4)*	0.772 (<0.001)	35.2 +/− 28.4

* P < 0.001, when compared to CL_CR ** P < 0.05, when compared to CL_CR.
CL_CR = 8-hr Creatinine Clearance, CG CL_CR = Cockcroft-Gault Creatinine Clearance, 175 eGFR = Abbreviated Modification of Diet in Renal Disease 175 formula, CKD-EPI eGFR = Chronic Kidney Disease Epidemiology Collaboration Equation, r = Pearson correlation coefficient.

ISSN: 1471-2369