Table 2 Baseline, follow-up and absolute changes (from baseline) for serum creatinine, eGFR, urine NGAL and delta of urine NGAL in each group of all patients (2A), CKD stage III (2B) and CKD stage IV (2C)

Serum creatinine (mg/dL)

Baseline

1.4 ± 0.4

2.0 ± 0.6^a

2.0 ± 0.6^a

1.9 ± 0.3^a

Follow-up (48 hr after)

1.3 ± 0.4

3.1 ± 1.1^a

2.7 ± 1.1^a

4.5 ± 0.4^a,b

Absolute change

0.0 ± 0.2

1.1 ± 0.9^a

0.7 ± 0.9^a

2.7 ± 0.6^a,b

eGFR (ml/min)

Baseline

44 ± 16

27 ± 7^a

27 ± 8^a

28 ± 3^a

Follow-up (48 hr after)

45 ± 17

18 ± 6^a

20 ± 6^a

11 ± 2^a,b

Absolute change

1 ± 5

-9 ± 5^a

-7 ± 3^a

-17 ± 2^a,b

Urine NGAL (ng/ml)

Baseline

68 ± 99

144 ± 111^a

154 ± 143^a

113 ± 45^a

3 h

79 ± 102

211 ± 120^a

213 ± 159^a

202 ± 60^a

6 h

93 ± 129

267 ± 153^a

255 ± 191^a

316 ± 86^a

12 h

115 ± 166

277 ± 169^a

256 ± 181^a

352 ± 133^a

18 h

132 ± 175

298 ± 171^a

315 ± 187^a

272 ± 80^a

24 h

122 ± 165

294 ± 162^a

314 ± 173^a

265 ± 52^a

Delta urine NGAL (ng/ml)

0-3 h

10 ± 92

66 ± 78^a

59 ± 81^a

99 ± 61^a

0-6 h

24 ± 110

122 ± 87^a

101 ± 72^a

213 ± 101^a,b

0-12 h

42 ± 158

132 ± 91^a

112 ± 76^a

242 ± 104^a,b

0-18 h

59 ± 142

135 ± 136^a

137 ± 147^a

159 ± 95^a

0-24 h

49 ± 149

149 ± 136^a

160 ± 136^a

151 ± 80^a

2B

Characteristic

CKD stage III

No CI-AKI)

CI-AKI

CI-AKI (S1)

CI-AKI (S2)

(N = 90

(N = 10)

(N = 9)

(N = 1)

Serum creatinine (mg/dL)

Baseline

1.3 ± 0.3

1.5 ± 0.5

1.5 ± 0.7

1.6

Follow-up (48 hr after)

1.2 ± 0.3

2.7 ± 1.0^a

2.5 ± 0.9^a

4.6^a,b

Absolute change

-0.1 ± 0.2

1.1 ± 0.8^a

0.9 ± 0.3^a

3.0^a,b

eGFR (ml/min)

Baseline

46 ± 14

44 ± 9

43 ± 9

43

Follow-up (48 hr after)

48 ± 11

22 ± 8^a

24 ± 8^a

14^a,b

Absolute change

1 ± 6

-22 ± 9^a

-18 ± 6^a

-29^a,b

Urine NGAL (ng/ml)

Baseline

61 ± 81

72 ± 45

75 ± 42

98

3 h

75 ± 83

145 ± 73^a

136 ± 72^a

220^a

6 h

84 ± 119

171 ± 75^a

160 ± 70^a

264^a

12 h

113 ± 162

181 ± 86^a

178 ± 78^a

208^a

18 h

121 ± 161

205 ± 210^a

203 ± 79^a

226^a

24 h

114 ± 163

210 ± 87^a

210 ± 93^a

204^a

Delta of urine NGAL (ng/ml)

0-3 h

13 ± 80

63 ± 42^a

62 ± 64^a

122^a

0-6 h

22 ± 104

89 ± 87^a

85 ± 86^a

166^a

0-12 h

49 ± 136

99 ± 91^a

103 ± 63^a

110^a

0-18 h

54 ± 131

124 ± 136^a

128 ± 55^a

128^a

0-24 h

46 ± 143

128 ± 136^a

135 ± 82^a

106^a

2C

Characteristic

CKD stage IV

No CI-AKI

CI-AKI

CI-AKI (S1)

CI-AKI (S2)

(N = 24)

(N = 6)

(N = 4)

(N = 2)

Serum creatinine (mg/dL)

Baseline

1.7 ± 0.5

2.4 ± 0.6^a

2.3 ± 0.6^a

2.5 ± 0.3^a

Follow-up (48 hr after)

1.6 ± 0.6

3.3 ± 1.3^a

2.9 ± 0.9^a

4.5 ± 0.6^a,b

Absolute change

-0.1 ± 0.3

1.0 ± 1.2^a

0.6 ± 0.4^a

2.1 ± 0.8^a,b

eGFR (ml/min)

Baseline

27 ± 3

20 ± 4^a

21 ± 5^a

19 ± 3^a

Follow-up (48 hr after)

27 ± 4

14 ± 6^a

15 ± 8^a

9 ± 4^a,b

Absolute change

0 ± 3

-7 ± 6^a

-6 ± 4^a

-10 ± 4^a,b

Urine NGAL (ng/ml)

Baseline

102 ± 98

217 ± 180^a

216 ± 231^a

218 ± 145^a

3 h

116 ± 157

314 ± 251^a

340 ± 318^a

261 ± 153^a

6 h

134 ± 162

404 ± 227^a

444 ± 280^a

324 ± 124^a

12 h

132 ± 191

409 ± 192^a

415 ± 239^a

396 ± 107^a

18 h

193 ± 230

394 ± 221^a

348 ± 226^a

349 ± 169^a

24 h

164 ± 182

385 ± 216^a

362 ± 131^a

329 ± 148^a

Delta of urine NGAL (ng/ml)

0-3 h

10 ± 156

97 ± 92^a

124 ± 106^a

84 ± 138^a

0-6 h

33 ± 131

187 ± 103^a

227 ± 101^a

217 ± 159^a

0-12 h

20 ± 227

192 ± 108^a

198 ± 108^a

248 ± 152^a

0-18 h

62 ± 186

112 ± 208^a

132 ± 112^a

162 ± 183^a,

0-24 h

63 ± 174

168 ± 212^a

145 ± 110^a

212 ± 192^a,