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Table 3 Diagnostic characteristics of urine NGAL for CI-AKI, stratified by baseline and postoperative time in all patient (3A), CKD stage III and CKD stage IV (3B)

From: Urinary Neutrophil Gelatinase-Associated Lipocalin predicts the severity of contrast-induced acute kidney injury in chronic kidney disease patients undergoing elective coronary procedures

3A

All patients (N = 130)

    
 

ROC (95% CI)

Cut point (ng/ml)

Sensitivity (%)

Specificity (%)

    

uNGAL

        

baseline

0.78 (0.68 to 0.87)

75

77

74

    

3 h

0.80 (0.69 to 0.89)

104

77

76

    

6 h

0.85 (0.76 to 0.91)

117

94

78

    

12 h

0.82 (0.74 to 0.90)

142

88

76

    

18 h

0.84 (0.76 to 0.91)

161

82

76

    

24 h

0.86 (0.79 to 0.93)

184

82

81

    

Delta of uNGAL

        

0-3 h

0.66 (0.49 to 0.79)

22

85

78

    

0-6 h

0.83 (0.75 to 0.92)

45

88

80

    

0-12 h

0.80 (0.72 to 0.89)

71

88

79

    

0-18 h

0.78 (0.67 to 0.90)

77

82

73

    

0-24 h

0.79 (0.67 to 0.91)

71

77

74

    

3B

 

CKD stage III (N = 100)

CKD stage IV (N = 30)

 

ROC (95% CI)

Cut point (ng/ml)

Sensitivity (%)

Specificity (%)

ROC (95% CI)

Cut point (ng/ml)

Sensitivity (%)

Specificity (%)

uNGAL

        

baseline

0.72 (0.61 to 0.83)

61

70

71

0.87 (0.73 to 1.0)

84

86

73

3 h

0.79 (0.65 to 0.93)

108

80

78

0.88 (0.75 to 1.0)

155

86

82

6 h

0.82 (0.72 to 0.92)

117

92

80

0.89 (0.80 to 1.0)

207

86

86

12 h

0.77 (0.67 to 0.88)

142

84

75

0.86 (0.72 to 0.99)

281

86

83

18 h

0.81 (0.72 to 0.89)

161

70

76

0.83 (0.68 to 0.97)

285

83

78

24 h

0.82 (0.74 to 0.92)

184

78

81

0.88 (0.75 to 1.0)

235

86

83

Delta of uNGAL

        

0-3 h

0.80 (0.64 to 0.96)

24

90

78

0.75 (0.49 to 1.0)

22

86

78

0-6 h

0.82 (0.69 to 0.95)

42

91

79

0.89 (0.77 to 1.0)

54

100

87

0-12 h

0.76 (0.64 to 0.88)

65

82

77

0.88 (0.75 to 1.0)

71

100

83

0-18 h

0.80 (0.71 to 0.89)

77

88

73

0.73 (0.47 to 1.0)

102

86

83

0-24 h

0.81 (0.70 to 0.91)

61

80

74

0.73 (0.47 to 0.99)

91

71

78