3A | ||||||||
---|---|---|---|---|---|---|---|---|
All patients (N = 130) | Â | Â | Â | Â | ||||
 | ROC (95% CI) | Cut point (ng/ml) | Sensitivity (%) | Specificity (%) |  |  |  |  |
uNGAL | Â | Â | Â | Â | Â | Â | Â | Â |
baseline | 0.78 (0.68 to 0.87) | 75 | 77 | 74 | Â | Â | Â | Â |
3 h | 0.80 (0.69 to 0.89) | 104 | 77 | 76 | Â | Â | Â | Â |
6 h | 0.85 (0.76 to 0.91) | 117 | 94 | 78 | Â | Â | Â | Â |
12 h | 0.82 (0.74 to 0.90) | 142 | 88 | 76 | Â | Â | Â | Â |
18 h | 0.84 (0.76 to 0.91) | 161 | 82 | 76 | Â | Â | Â | Â |
24 h | 0.86 (0.79 to 0.93) | 184 | 82 | 81 | Â | Â | Â | Â |
Delta of uNGAL | Â | Â | Â | Â | Â | Â | Â | Â |
0-3 h | 0.66 (0.49 to 0.79) | 22 | 85 | 78 | Â | Â | Â | Â |
0-6 h | 0.83 (0.75 to 0.92) | 45 | 88 | 80 | Â | Â | Â | Â |
0-12 h | 0.80 (0.72 to 0.89) | 71 | 88 | 79 | Â | Â | Â | Â |
0-18 h | 0.78 (0.67 to 0.90) | 77 | 82 | 73 | Â | Â | Â | Â |
0-24 h | 0.79 (0.67 to 0.91) | 71 | 77 | 74 | Â | Â | Â | Â |
3B | ||||||||
 | CKD stage III (N = 100) | CKD stage IV (N = 30) | ||||||
 | ROC (95% CI) | Cut point (ng/ml) | Sensitivity (%) | Specificity (%) | ROC (95% CI) | Cut point (ng/ml) | Sensitivity (%) | Specificity (%) |
uNGAL | Â | Â | Â | Â | Â | Â | Â | Â |
baseline | 0.72 (0.61 to 0.83) | 61 | 70 | 71 | 0.87 (0.73 to 1.0) | 84 | 86 | 73 |
3 h | 0.79 (0.65 to 0.93) | 108 | 80 | 78 | 0.88 (0.75 to 1.0) | 155 | 86 | 82 |
6 h | 0.82 (0.72 to 0.92) | 117 | 92 | 80 | 0.89 (0.80 to 1.0) | 207 | 86 | 86 |
12 h | 0.77 (0.67 to 0.88) | 142 | 84 | 75 | 0.86 (0.72 to 0.99) | 281 | 86 | 83 |
18 h | 0.81 (0.72 to 0.89) | 161 | 70 | 76 | 0.83 (0.68 to 0.97) | 285 | 83 | 78 |
24 h | 0.82 (0.74 to 0.92) | 184 | 78 | 81 | 0.88 (0.75 to 1.0) | 235 | 86 | 83 |
Delta of uNGAL | Â | Â | Â | Â | Â | Â | Â | Â |
0-3 h | 0.80 (0.64 to 0.96) | 24 | 90 | 78 | 0.75 (0.49 to 1.0) | 22 | 86 | 78 |
0-6 h | 0.82 (0.69 to 0.95) | 42 | 91 | 79 | 0.89 (0.77 to 1.0) | 54 | 100 | 87 |
0-12 h | 0.76 (0.64 to 0.88) | 65 | 82 | 77 | 0.88 (0.75 to 1.0) | 71 | 100 | 83 |
0-18 h | 0.80 (0.71 to 0.89) | 77 | 88 | 73 | 0.73 (0.47 to 1.0) | 102 | 86 | 83 |
0-24 h | 0.81 (0.70 to 0.91) | 61 | 80 | 74 | 0.73 (0.47 to 0.99) | 91 | 71 | 78 |