Table 4 Diagnostic characteristics of urine NGAL for CI-AKI stage I, stratified by baseline and postoperative time in all patient (4A), CKD stage III and CKD stage IV (4B)

uNGAL

baseline

0.77 (0.65 to 0.89)

74

77

72

3 h

0.82 (0.71 to 0.94)

108

85

76

6 h

0.83 (0.74 to 0.92)

117

92

76

12 h

0.82(0.72 to 0.91)

142

85

73

18 h

0.84 (0.76 to 0.92)

161

83

74

24 h

0.85 (0.77 to 0.93)

181

85

79

Delta of uNGAL

0-3 h

0.75 (0.58 to 0.91)

22

85

78

0-6 h

0.82 (0.72 to 0.92)

54

85

80

0-12 h

0.79 (0.68 to 0.88)

71

85

76

0-18 h

0.77 (0.63 to 0.91)

77

92

72

0-24 h

0.77 (0.62 to 0.92)

71

77

73

4B

CKD stage III (N = 100)

CKD stage IV (N = 30)

ROC (95% CI)

Cut point (ng/ml)

Sensitivity (%)

Specificity (%)

ROC (95% CI)

Cut point (ng/ml)

Sensitivity (%)

Specificity (%)

uNGAL

baseline

0.70 (0.58 - 0.81)

41

78

58

0.90 (0.78 - 1.0)

140

100

88

3 h

0.77 (0.62 - 0.92)

108

78

78

0.89 (0.77 - 1.0)

162

100

79

6 h

0.80 (0.70 - 0.91)

117

89

79

0.89 (0.75 - 1.0)

239

100

80

12 h

0.76 (0.69 - 0.87)

142

78

74

0.83 (0.66 1.0)

276

100

63

18 h

0.80 (0.70 - 0.89)

130

78

72

0.85 (0.68 - 1.0)

242

100

73

24 h

0.82 (0.72 - 0.92)

160

78

79

0.90 (0.78 - 1.0)

184

100

77

Delta of uNGAL

0-3 h

0.79 (0.62 - 0.96)

24

89

77

0.81 (0.64 - 0.97)

22

100

73

0-6 h

0.80 (0.66 - 0.94)

42

89

78

0.84 (0.70 - 0.98)

65

100

77

0-12 h

0.75 (0.63 - 0.89)

74

78

77

0.82 (0.66 - 0.97)

71

100

76

0-18 h

0.81 (0.71 - 0.90)

77

89

73

0.61 (0.19 - 1.0)

102

75

73

0-24 h

0.81 (0.70 - 0.90)

71

78

77

0.62 (0.19 - 1.0)

44

75

54