Table 5 Diagnostic characteristics of urine NGAL for CI-AKI stage II, stratified by baseline and postoperative time in all patient (5A), CKD stage III and CKD stage IV (5B)

uNGAL

baseline

0.76 (0.65 to 0.88)

82

100

70

3 h

0.86 (0.76 to 0.97)

135

100

77

6 h

0.9 (0.84 to 0.97)

264

100

87

12 h

0.85 (0.74 to 0.96)

204

100

79

18 h

0.8 (0.72 to 0.88)

186

100

76

24 h

0.78 (0.7 to 0.86)

175

100

74

Delta of uNGAL

0-3 h

0.87 (0.77 to 0.97)

53

100

81

0-6 h

0.93 (0.86 to 0.99)

121

100

87

0-12 h

0.82 (0.67 to 0.98)

65

100

71

0-18 h

0.77 (0.63 to 0.91)

83

100

67

0-24 h

0.76 (0.64 to 0.88)

61

100

68

5B

CKD stage III (N = 100)

CKD stage IV (N = 30)

ROC (95% CI)

Cut point (ng/ml)

Sensitivity (%)

Specificity (%)

ROC (95% CI)

Cut point (ng/ml)

Sensitivity (%)

Specificity (%)

uNGAL

baseline

0.88 (0.0 to 1.0)

143

100

88

0.60 (0.42 to 0.79)

82

100

59

3 h

0.92 (0.0 to 1.0)

220

100

92

0.74 (0.48 to 1.0)

135

100

63

6 h

0.93 (0.0 to 1.0)

264

100

93

0.80 (0.56 to 1.0)

281

100

71

12 h

0.83 (0.0 to 1.0)

208

100

83

0.77 (0.51 to 1.0)

204

100

65

18 h

0.83 (0.0 to 1.0)

226

100

83

0.67 (0.48 to 0.85)

186

100

63

24 h

0.81 (0.0 to 1.0)

204

100

81

0.70 (0.52 to 0.87)

175

100

68

Delta of uNGAL

0-3 h

0.84 (0.0 to 1.0)

77

100

84

0.88 (0.72 to 1.0)

53

100

82

0-6 h

0.90 (0.0 to 1.0)

121

100

90

0.91 (0.77 to 1.0)

197

100

86

0-12 h

0.72 (0.0 to 1.0)

65

100

72

0.88 (0.68 to 1.0)

120

100

78

0-18 h

0.69 (0.0 to 1.0)

83

100

69

0.78 (0.61 to 0.95)

102

100

71

0-24 h

0.70 (0.0 to 1.0)

61

100

70

0.79 (0.60 to 0.98)

91

100

71