Skip to main content

Table 4 Predictors of all-cause mortality in the study population

From: Lower serum sodium level predicts higher risk of infection-related hospitalization in maintenance hemodialysis patients: an observational cohort study

 

Univariate

Multivariatea

 

HR (95% CI)

p-value

HR (95% CI)

p-value

Serum sodium level

    

 Categorical model

    

 <138.0 mEq/L

2.06 (1.15–3.66)

0.014

1.57 (0.85–2.87)

0.148

 138.0 – 140.0 mEq/L

0.94 (0.49–1.81)

0.853

0.97 (0.50–1.89)

0.938

 >140.0 mEq/L

1 (ref)

 

1 (ref)

 

 Continuous model (per 1 mEq/L)

0.87 (0.81–0.95)

0.001

0.91 (0.83–1.00)

0.049

Age (per 5 years)

1.40 (1.25–1.57)

<0.001

1.24 (1.08–1.41)

0.002

Female (vs male)

0.76 (0.46–1.28)

0.302

  

Body mass index (per 1 kg/m2)

0.88 (0.81–0.95)

0.001

  

Smoking history

1.32 (0.81–2.13)

0.267

  

Inability to ambulate or transfer

4.13 (2.32–7.36)

<0.001

1.44 (0.69–2.99)

0.328

Comorbid conditions

    

 Diabetes mellitus

2.80 (1.73–4.54)

<0.001

1.98 (1.17–3.36)

0.011

 Hypertension

1.66 (0.52–5.30)

0.388

  

 Cardiovascular disease

2.36 (1.47–3.80)

<0.001

1.65 (0.98–2.76)

0.059

 Peripheral vascular disease

3.84 (1.90–7.75)

<0.001

1.89 (0.88–4.06)

0.104

 Cerebrovascular disease

2.07 (1.18–3.63)

0.011

  

 Chronic liver disease

1.63 (0.85–3.10)

0.140

  

 Cancer

2.82 (1.65–4.84)

<0.001

2.49 (1.39–4.46)

0.002

Dialysis vintage (per 12 months)

0.99 (0.95–1.02)

0.357

  

IDWL (per 1% of body weight)

1.02 (0.85–1.23)

0.824

  

Vascular access

    

 Fistula

1 (ref)

   

 Graft or catheter

2.14 (1.20–3.79)

0.010

  

Laboratory data

    

 Hemoglobin (per 1 g/dL)

0.82 (0.62–1.07)

0.140

  

 Serum albumin (per 1 g/dL)

0.16 (0.08–0.32)

<0.001

0.65 (0.24–1.74)

0.388

 Serum creatinine (per 1 mg/dL)

0.76 (0.69–0.83)

<0.001

0.93 (0.81–1.06)

0.272

 Serum β2-microglobulin (per 5 mg/dL)

1.26 (1.03–1.54)

0.027

  
  1. aAdjustments in serum sodium level, all covariates, which were correlated with the outcome, with p < 0.001 at univariate analyses including age, inability to ambulate or transfer, diabetes mellitus, cardiovascular disease, peripheral vascular disease, cancer, serum albumin, and serum creatinine, and also determinants of baseline serum sodium level at multivariate linear regression analyses including IDWL and hemoglobin.
  2. Abbreviations: CI confidence interval, HR hazard ratio, IDWL intradialytic weight loss.