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Figure 1 | BMC Nephrology

Figure 1

From: Intracellular calcium release modulates polycystin-2 trafficking

Figure 1

PC2 trafficking to the PM in human proximal tubule (hPT) cells. ( A-F ). Immunocytochemistry of PC2 in hRT cells treated with control ( A ), 1 μM ouabain ( C ), or 25 μM ATP ( E ). Scale bars, 20 μm. Localization profile of PC2 along a line (as indicated) through the center of a single hPT cell treated with control ( B ), ouabain ( D ), or ATP ( F ). Gray areas represent PM regions. ( G ) Quantitative analysis of a number of PM PC2-positive hRT cells following indicated treatments. Values are the mean ± SEM, and ***P < 0.001 vs. control.

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