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Table 3 Odds ratios (ORs) and 95% confidence intervals (CIs) for decreased eGFR (< 90 ml/min/1.73 m 2 ) by Mt5178 C/A genotype and alcohol consumption

From: Combined effect of mitochondrial DNA 5178 C/A polymorphism and alcohol consumption on estimated glomerular filtration rate in male Japanese health check-up examinees: a cross-sectional study

Genotype and alcohol consumption

Frequency (%)

OR (95% CI)

Adjusted OR† (95% CI)

Adjusted OR‡ (95% CI)

eGFR ≥ 90 ml/min/1.73 m2

eGFR < 90 ml/min/1.73 m2

Mt5178C (N = 239)

     

Non-drinkers

6 (13.6)

38 (86.4)

1 (reference)

1 (reference)

1 (reference)

Occasional drinkers

20 (23.8)

64 (76.2)

0.505 (0.186–1.369)

0.633 (0.222–1.810)

0.786 (0.261–2.372)

Daily drinkers

16 (14.4)

95 (85.6)

0.938 (0.341–2.576)

1.038 (0.359–2.999)

1.024 (0.339–3.092)

   

P for trend = 0.690

P for trend = 0.587

P for trend = 0.587

Mt5178A (N = 155)

     

Non-drinkers

1 (4.8)

20 (95.2)

1 (reference)

1 (reference)

1 (reference)

Occasional drinkers

12 (20.0)

48 (80.0)

0.200 (0.024–1.642)

0.276 (0.032–2.395)

0.280 (0.031–2.505)

Daily drinkers

26 (35.1)

48 (64.9)

0.092 (0.012–0.727)*

0.098 (0.012–0.784)*

0.091 (0.011–0.747)*

   

P for trend = 0.003

P for trend = 0.004

P for trend = 0.004

  1. eGFR; estimated glomerular filtration rate. †OR adjusted for age and body mass index. ‡OR adjusted for age, body mass index, habitual smoking, coffee consumption and antihypertensive medication. *P < 0.05.