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Table 2 Animal growth and blood values during 12 weeks of treatment with cyclosporine A with/without eplerenone

From: The mineralocorticoid receptor antagonist eplerenone reduces renal interstitial fibrosis after long-term cyclosporine treatment in rat: antagonizing cyclosporine nephrotoxicity

Variables

Units

CsA

CsA + EPL

Controls

N

 

8

9

11

Increase in BW

grams/week

13.4*± 5.2

22.2± 4.0

23.0± 5.0

Body weight

g

372* ± 14

461 ± 16

486 ± 13

Kidney weight (right)

g

1.4 ± 0.2

1.7 ± 0.2

1.6 ± 0.2

Kidney weight (total)/BW ratio

mg/g

7.8 ± 1.6

7.4 ± 1.2

6.6 ± 0.8

P potassium

mmol/l

5.1 ± 0.9

5.1 ± 0.4

4.8 ± 0.3

P sodium

mmol/l

140.9 ± 4.9

141.7 ± 4.6

143.0 ± 3.7

P renin

mIU/l

7.4 ± 1.9

12.7 ± 3.9*

4.0 ± 1.1

P aldosterone

pg/ml

65 ± 14

493 ± 135*

57 ± 17

B cyclosporine

ng/ml

3423 ± 549

2346 ± 254

0

  1. B: Whole blood. BW: Body weight. CsA: cyclosporine A. EPL: eplerenone. P: plasma.
  2. Results are shown as mean values +/− SEM.
  3. *: p<0.05 when compared to the control group.