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Table 1 Baseline and intraoperative characteristics of the liver transplantation cohort stratified by time from AKI to RRT or serum creatinine peak

From: Impact of acute kidney injury exposure period among liver transplantation patients

  Time from AKI onset to RRT or SCr peak
  Less than a week (N = 221) A week or more (N = 94) Totals (N=315) p value
Age (years) 53 (46 – 60) 53 (45 – 58) 53 (46 – 60) 0.502
Weight (kg) 72 (62 – 81) 72 (60 – 82) 72 (62 – 82) 0.538
Height (cm) 169 (162 – 174) 168 (160 – 175) 169 (162 – 174) 0.446
Men 148 (67%) 59 (63%) 207 (66%) 0.472
Diabetes mellitus 42 (19%) 23 (24%) 65 (21%) 0.273
Hypertension 16 (7%) 8 (8%) 24 (8%) 0.697
Smoking habit 10 (4%) 1 (1%) 11 (4%) 0.126
eGFR (MDRD) 92 (74 – 113) 96 (76 – 110) 93 (74 – 112) 0.508
Previous serum creatinine (mg/dl) 0.8 (0.7 – 1.0) 0.8 (0.7 – 1.0) 0.8 (0.7 – 1.0) 0.385
Serum albumin (mg/dl) 3.1 (2.7 – 3.4) 3.1 (2.8 – 3.5) 3.1 (2.7 – 3.5) 0.100
Total bilirubin (mg/dl) 2.6 (1.7 – 4.1) 2.4 (1.6 – 3.8) 2.6 (1.7 – 4.0) 0.419
Main Indication for LT     
  Hepatitis B 22 (10%) 12 (13%) 34 (11%) 0.462
  Hepatitis C 110 (50%) 48 (51%) 158 (50%) 0.834
  Alcoholic cirrhosis 55 (25%) 21 (22%) 76 (24%) 0.629
  Acute liver failure 6 (19%) 3 (3%) 9 (3%) 0.816
  Liver malignancy 48 (22%) 27 (29%) 75 (24%) 0.182
  Other cirrhotic 43 (19%) 18 (19%) 61 (19%) 0.950
MELD score 14 (10 – 18) 12 (9 – 15) 13 (9 – 17) 0.067
Child-Pugh stage     0.075
  A 32 (14%) 22 (23%) 54 (17%)  
  B 110 (50%) 48 (51%) 158 (50%)  
  C 79 (36%) 24 (26%) 103 (33%)  
Deceased liver donor 126 (57%) 55 (58%) 181 (58%) 0.806
Piggyback technique 214 (97%) 92 (98%) 306 (97%) 0.612
Total ischemia time (h) 6.6 (2.4 – 10) 6.9 (2.5 – 10) 6.7 (2.4 – 10) 0.716
Surgical time (h) 7.8 (7 – 8.5) 7.5 (7 – 8.5) 7.6 (7 – 8.5) 0.405
Blood products (units) 4 (2 – 9) 3 (1 – 5) 4 (2 – 8) 0.027
Aprotinin 65 (29%) 18 (19%) 83 (26%) 0.059
Intraoperative pressor 20 (9%) 5 (5%) 25 (8%) 0.262
APACHE II score 15 (13 – 19) 16 (14 – 19) 16 (13 – 19) 0.243
  1. AKI: acute kidney injury; APACHE: Acute Physiology and Chronic Disease Health Evaluation; eGFR: estimated glomerular filtration rate; LT: liver transplantation; MDRD: Modification of Diet in Renal Disease; MELD: Model for End Stage Liver Disease; RRT: renal replacement therapy; SCr: serum creatinine.