Table 2 Hyporesponsiveness categories for total erythropoietin dose
Hyporesponsiveness | Squared difference | ||||||
|---|---|---|---|---|---|---|---|
All | None | Chronic | Acute | Other | Other - chronic | Other - acute | |
n | 138,688 | 111,422 | 6248 | 7219 | 13,799 | ||
Sex | |||||||
Men | 51.8 | 51.6 | 54.7 | 51.0 | 52.5 | 4.9 | 2.3 |
Women | 48.2 | 48.4 | 45.3 | 49.0 | 47.5 | ||
Race | |||||||
White | 51.4 | 52.6 | 46.2 | 47.4 | 46.0 | 0.1 | 1.8 |
African American | 42.2 | 40.5 | 49.8 | 47.5 | 49.5 | 0.1 | 4.1 |
Other | 6.4 | 6.9 | 3.9 | 5.1 | 4.4 | ||
Age, years | |||||||
< 40 | 8.1 | 7.5 | 12.9 | 9.8 | 10.3 | 7.0 | 0.2 |
40-64 | 44.3 | 42.7 | 54.9 | 48.3 | 50.3 | 20.6 | 4.1 |
65-74 | 24.9 | 25.5 | 19.8 | 24.5 | 22.8 | 9.3 | 2.9 |
≥ 75 | 22.7 | 24.4 | 12.5 | 17.4 | 16.6 | ||
Cause of renal failure | |||||||
Diabetes | 44.9 | 45.3 | 38.7 | 45.7 | 44.1 | 29.0 | 2.8 |
Hypertension | 29.3 | 29.6 | 27.8 | 27.8 | 28.8 | 1.0 | 1.1 |
Glomerulonephritis | 10.2 | 10.0 | 12.2 | 10.3 | 10.7 | 2.2 | 0.1 |
Cystic kidney disease | 2.2 | 2.2 | 2.1 | 2.0 | 1.8 | 0.1 | 0.1 |
Other | 13.5 | 13.0 | 19.3 | 14.2 | 14.7 | ||
Dialysis duration, years | |||||||
< 1 | 9.6 | 9.8 | 7.7 | 9.4 | 8.6 | 0.9 | 0.5 |
1 to < 3 | 32.6 | 33.5 | 26.3 | 31.3 | 28.9 | 6.7 | 5.8 |
3 to < 5 | 23.6 | 23.6 | 23.2 | 23.0 | 23.8 | 0.3 | 0.7 |
≥ 5 | 34.3 | 33.1 | 42.8 | 36.4 | 38.7 | ||
Average BMI, kg/m 2 | |||||||
< 18.5 | 3.7 | 3.6 | 3.3 | 4.3 | 3.8 | 0.2 | 0.3 |
≥ 18.5 and < 25 | 34.9 | 35.2 | 30.4 | 36.5 | 33.5 | 9.4 | 8.8 |
≥ 25 and < 30 | 28.5 | 28.9 | 25.6 | 27.6 | 27.3 | 2.8 | 0.1 |
≥ 30 | 33.0 | 32.3 | 40.7 | 31.6 | 35.4 | ||
Antecedent comorbid conditions | |||||||
ASHD | 22.0 | 20.4 | 26.0 | 29.8 | 28.5 | 6.3 | 1.6 |
CHF | 19.6 | 17.2 | 29.9 | 29.7 | 28.8 | 1.3 | 0.8 |
CVA/TIA | 7.4 | 6.9 | 7.5 | 10.9 | 9.6 | 4.0 | 1.9 |
PVD | 16.5 | 14.8 | 23.1 | 24.2 | 23.3 | 0.1 | 0.9 |
Other cardiac disease | 12.4 | 10.6 | 20.3 | 20.0 | 19.2 | 1.1 | 0.6 |
COPD | 8.4 | 7.3 | 13.2 | 12.7 | 12.9 | 0.1 | 0.0 |
GI bleeding | 3.3 | 2.5 | 7.2 | 6.1 | 6.1 | 1.2 | 0.0 |
Liver disease | 5.5 | 5.2 | 7.4 | 6.3 | 6.8 | 0.3 | 0.3 |
Dysrhythmia | 13.7 | 12.4 | 19.1 | 19.2 | 18.8 | 0.0 | 0.1 |
Cancer | 4.1 | 3.6 | 7.2 | 5.3 | 5.8 | 2.1 | 0.2 |
Diabetes | 49.7 | 48.9 | 49.2 | 55.0 | 53.0 | 14.1 | 4.1 |
Concurrent comorbid conditions | |||||||
ASHD | 30.1 | 28.4 | 32.9 | 41.2 | 37.0 | 16.8 | 17.3 |
CHF | 27.6 | 24.6 | 38.9 | 42.9 | 39.1 | 0.0 | 14.7 |
CVA/TIA | 10.9 | 10.2 | 10.5 | 16.9 | 13.5 | 9.3 | 11.3 |
PVD | 24.8 | 22.8 | 30.3 | 35.8 | 32.7 | 5.6 | 10.0 |
Other cardiac disease | 19.7 | 17.2 | 28.3 | 32.4 | 28.8 | 0.3 | 12.5 |
COPD | 12.5 | 11.1 | 18.2 | 19.2 | 17.9 | 0.1 | 1.6 |
GI bleeding | 5.3 | 4.1 | 10.6 | 11.2 | 9.6 | 1.0 | 2.7 |
Liver disease | 6.4 | 6.0 | 8.9 | 7.8 | 8.0 | 0.9 | 0.0 |
Dysrhythmia | 19.8 | 18.1 | 25.1 | 28.4 | 26.4 | 1.8 | 3.9 |
Cancer | 5.6 | 5.0 | 9.9 | 7.2 | 7.6 | 5.5 | 0.1 |
Diabetes | 57.3 | 56.7 | 55.6 | 62.1 | 60.2 | 20.8 | 3.7 |
Number of vascular access complication | |||||||
0 | 61.9 | 61.9 | 64.0 | 55.4 | 53.7 | 106.1 | 2.7 |
1-3 | 19.9 | 19.9 | 19.1 | 21.7 | 23.4 | 17.8 | 2.7 |
≥ 4 | 18.2 | 18.2 | 16.9 | 22.9 | 22.9 | ||
Average iron dose per month, mg | |||||||
Non-users | 15.1 | 16.2 | 13.0 | 9.5 | 10.4 | 7.1 | 0.7 |
< 233 | 21.1 | 23.0 | 11.4 | 14.6 | 13.9 | 6.6 | 0.5 |
≥ 233 and < 360 | 21.1 | 21.5 | 16.6 | 20.2 | 20.1 | 12.0 | 0.0 |
≥ 360 and < 460 | 20.9 | 20.5 | 20.9 | 23.9 | 22.5 | 2.5 | 2.0 |
≥ 460 | 21.8 | 18.8 | 38.1 | 31.8 | 33.2 | 24.5 | 1.9 |
IV antibiotic use | |||||||
No | 76.9 | 76.9 | 79.6 | 65.6 | 66.6 | 168.0 | 1.0 |
Yes | 23.1 | 23.1 | 20.5 | 34.4 | 33.4 | ||
Number of hospital admissions | |||||||
0 | 63.3 | 63.3 | 68.3 | 45.7 | 44.8 | 549.0 | 0.8 |
1 | 20.8 | 20.8 | 19.4 | 26.7 | 26.0 | 43.2 | 0.5 |
≥ 2 | 15.9 | 15.9 | 12.3 | 27.6 | 29.2 | ||
Number of hospitalization days | |||||||
0 | 63.3 | 63.3 | 68.3 | 45.7 | 44.8 | 549.0 | 0.8 |
1-7 | 18.4 | 18.4 | 17.3 | 24.4 | 22.4 | 25.6 | 4.2 |
≥ 8 | 18.4 | 18.4 | 14.4 | 29.8 | 32.8 | ||
Infectious hospitalizations | |||||||
No | 88.2 | 88.2 | 90.6 | 80.3 | 79.2 | 129.8 | 1.2 |
Yes | 11.8 | 11.8 | 9.4 | 19.7 | 20.8 | ||
Dialysis provider | |||||||
Non-profit | 14.0 | 14.0 | 14.7 | 12.4 | 11.0 | 13.0 | 1.7 |
For profit | 85.0 | 85.0 | 84.4 | 86.5 | 87.6 | 9.8 | 1.1 |
Unknown | 1.0 | 1.0 | 0.9 | 1.1 | 1.4 | ||
Region | |||||||
Northeast | 15.7 | 15.7 | 15.7 | 15.0 | 15.1 | 0.4 | 0.0 |
Midwest | 19.1 | 19.1 | 19.4 | 19.0 | 17.8 | 2.6 | 1.5 |
South | 45.2 | 45.2 | 43.7 | 50.8 | 51.9 | 67.9 | 1.2 |
West | 17.2 | 17.2 | 18.3 | 12.6 | 12.6 | 33.1 | 0.0 |
Unknown | 2.8 | 2.8 | 2.9 | 2.7 | 2.7 | ||
Distance | -- | -- | -- | -- | -- | 43.6 | 12.0 |