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Table 1 Baseline characteristics of patients with FSGS and comparison of baseline characteristics between patients with and without FSGS recurrence

From: A retrospective study of focal segmental glomerulosclerosis: clinical criteria can identify patients at high risk for recurrent disease after first renal transplantation

 

Total population (n=94)

Recurrence (n=28)

No recurrence (n=66)

P-value (difference recurrence vs no recurrence group)

Sex (M/F)

51/43

16/12

35/31

0.82

Age at onset (yr)

26 (1–61)

19 (4–57)

26 (1–61)

0.63

Age at diagnosis (yr)*

28 (2–62)

23 (5–57)

29 (2–62)

0.25

Serum albumin at diagnosis (g/l)

27 ± 11 (n=60)

20 ± 9 (n=20)

31 ± 10 (n= 40)

<0.01

24-hour protein exretion (g)

8.0 ± 7.3 (n=42)

11.7 ± 8.8 (n=15)

5.9 ± 5.5 (n=27)

0.01

eGFR at diagnosis† (ml/min/1.73 m2)

81 ± 53 (n=63)

104 ± 50 (n=21)

69 ± 51 (n=42)

0.01

Cause of FSGS

Familial/geneticFSGS (group I)

18 (19%)

0

18

<0.01

Secondary FSGS (group II)

10 (11%)

0

10

Idiopathic FSGS (group III)

66 (70%)

28

38

Bilateral nephrectomy before transplantation

6

1

5

0.67

Interval onset to diagnosis* (yr)

0.5 (0–31)

0.3 (0–6.9)

0.8 (0–31.0)

0.07

Interval diagnosis to ESRD (yr)

3.9 (0.1-32.4)

4.9 (0.1-16.8)

3.7 (0.1-32.4)

0.96

Interval ESRD to transplantation

1.4 (0–9.3)

1.2 (0–4.7)

1.4 (0–9.3)

0.53

Age at transplantation (yr)

37 (5–69)

32 (10–62)

38 (5–69)

0.17

Donor Source

Deceased

75

24

51

0.57

Living unrelated

7

1

6

Living related

12

3

9

Donor age (yr)

35.5 (0–68)

36.5 (5–64)

35.5 (0–68)

0.91

Number of HLA mismatches

2.0 ± 1.2

2.0 ± 1.2

2.0 ± 1.2

0.77

Initial immunosuppressive regimen

P + CsA

54

18

36

0.38

P + Aza

11

5

6

P + CsA + MMF

13

2

11

P + tacro + MMF

14

3

11

Dacl + tacro + MMF

2

0

2

  1. Data are given as n(%), means ± SD or median (range).
  2. *age at diagnosis is based on biopsy date. Two patients with familial FSGS were not biopsied. For these patients, age at diagnosis equals age of first presentation.
  3. †eGFR was calculated with the abbreviated MDRD study equation in adults and with Schwartz’ formula in children.
  4. P = prednisone, CsA = cyclosporine, Aza = azathioprine, MMF = mycophenolate mofetil, Tacro=tacrolimus, Dacl = daclizumab.
  5. eGFR = estimated glomerular filtration rate, ESRD = end-stage renal disease.