| Total population (n=94) | Recurrence (n=28) | No recurrence (n=66) | P-value (difference recurrence vs no recurrence group) | |
---|---|---|---|---|---|
Sex (M/F) | 51/43 | 16/12 | 35/31 | 0.82 | |
Age at onset (yr) | 26 (1–61) | 19 (4–57) | 26 (1–61) | 0.63 | |
Age at diagnosis (yr)* | 28 (2–62) | 23 (5–57) | 29 (2–62) | 0.25 | |
Serum albumin at diagnosis (g/l) | 27 ± 11 (n=60) | 20 ± 9 (n=20) | 31 ± 10 (n= 40) | <0.01 | |
24-hour protein exretion (g) | 8.0 ± 7.3 (n=42) | 11.7 ± 8.8 (n=15) | 5.9 ± 5.5 (n=27) | 0.01 | |
eGFR at diagnosis†(ml/min/1.73 m2) | 81 ± 53 (n=63) | 104 ± 50 (n=21) | 69 ± 51 (n=42) | 0.01 | |
Cause of FSGS | Familial/geneticFSGS (group I) | 18 (19%) | 0 | 18 | <0.01 |
Secondary FSGS (group II) | 10 (11%) | 0 | 10 | ||
Idiopathic FSGS (group III) | 66 (70%) | 28 | 38 | ||
Bilateral nephrectomy before transplantation | 6 | 1 | 5 | 0.67 | |
Interval onset to diagnosis* (yr) | 0.5 (0–31) | 0.3 (0–6.9) | 0.8 (0–31.0) | 0.07 | |
Interval diagnosis to ESRD (yr) | 3.9 (0.1-32.4) | 4.9 (0.1-16.8) | 3.7 (0.1-32.4) | 0.96 | |
Interval ESRD to transplantation | 1.4 (0–9.3) | 1.2 (0–4.7) | 1.4 (0–9.3) | 0.53 | |
Age at transplantation (yr) | 37 (5–69) | 32 (10–62) | 38 (5–69) | 0.17 | |
Donor Source | Deceased | 75 | 24 | 51 | 0.57 |
Living unrelated | 7 | 1 | 6 | ||
Living related | 12 | 3 | 9 | ||
Donor age (yr) | 35.5 (0–68) | 36.5 (5–64) | 35.5 (0–68) | 0.91 | |
Number of HLA mismatches | 2.0 ± 1.2 | 2.0 ± 1.2 | 2.0 ± 1.2 | 0.77 | |
Initial immunosuppressive regimen | P + CsA | 54 | 18 | 36 | 0.38 |
P + Aza | 11 | 5 | 6 | ||
P + CsA + MMF | 13 | 2 | 11 | ||
P + tacro + MMF | 14 | 3 | 11 | ||
Dacl + tacro + MMF | 2 | 0 | 2 |