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Table 2 Demographic and transplant-related factors, and laboratory results at diagnosis in patients with idiopathic FSGS (group III) with and without a recurrence

From: A retrospective study of focal segmental glomerulosclerosis: clinical criteria can identify patients at high risk for recurrent disease after first renal transplantation

 

Recurrence

No recurrence

P-value

N

28

38

 

Sex (M/F)

16/12

24/14

0.80

Age at presentation (yr)

19 (4–57)

28 (1–61)

0.45

Age at diagnosis (yr)

23 (5–57)

34 (2–61)

0.13

Body mass index at diagnosis in patients >16 yr (n=48)

24.6 ± 3.6 (n=12)

25.0 ± 3.5 (n=26)

0.76

eGFR at diagnosis (ml/min/1.73 m2)

104 ± 50 (n=21)

53 ± 22 (n=22)

<0.01

Serum albumin at diagnosis (g/l)

20 ± 9 (n=20)

33 ± 10 (n=24)

<0.01

24-hour protein excretion (g)

11.7 ± 8.8 (n=15)

4.6 ± 2.7 (n=14)

<0.01

Interval onset to diagnosis (yr)

0.3 (0–6.9)

1.0 (0–22)

<0.01

Interval diagnosis to ESRD (yr)

4.9 (0.1-16.8)

3.7 (0.2-32.4)

0.96

Interval ESRD to Tx (yr)

1.2 (0–4.7)

1.5 (0–9.3)

0.34

Age at transplantation (yr)

32 (10–62)

44 (5–68)

0.06

Donor age (yr)

36.5 (5–64)

38 (0–68)

0.60

Number of HLA mismatches

2.0 ± 1.2

2.1 ± 1.2

0.81

Donor source (n)

Deceased

24

27

0.35

Living unrelated

1

4

Living related

3

7

Baseline immunosuppressive regimen (n)

P, CsA

18

23

0.64

P, Aza

5

4

P, CsA, MMF

2

2

P, tacro, MMF

3

8

Dacl, tacro, MMF

0

1

  1. Data are given as n(%), means ±SD or median (range).
  2. P = prednisone, CsA = cyclosporine, Aza = azathioprine, MMF = mycophenolate mofetil, Tacro=tacrolimus.
  3. Dacl = daclizumab, eGFR = estimated glomerular filtration rate, ESRD = end-stage renal disease, Tx = transplantation.