The A736V TMPRSS6 polymorphism influences hepcidin and iron metabolism in chronic hemodialysis patients: TMPRSS6 and hepcidin in hemodialysis

Table 3 Clinical and genetic variables associated with hepcidin-25 levels at Spearman’s rho test (univariate analysis) and multivariate analysis in CHD patients from Northern Italy

	Univariate		GLM model 1		GLM model 2
	R	P	Estimate	p	Estimate	p
Ferritin ng/ml	+0.30	0.0001	0.27	0.004	0.27	0.005
CRP mg/dl	+0.29	0.0004	0.29	0.01	0.28	0.010
Transferrin mg/dl	−0.20	0.03	-	-	-	-
Epo IU/Kg/week	+0.16	0.06	0.18	0.94	-	-
HDL mg/dl	−0.20	0.06	-	-	-	-
Albumin g/l	−0.15	0.06	-	-	-	-
TMPRSS6 A/A HFE muts + vs. other genotypes	−0.19	0.02	-	-	−0.17	0.048

Generalized linear model (GLM) 1 included clinical variables correlated with hepcidin-25 at univariate analysis (reported for p < 0.1), which were available in the majority of patients, i.e. ferritin, CRP levels, and Epo dose (157 subjects included). The second model considered the major clinical independent determinants of hepcidin, plus the genetic factors analyzed (143 subjects included).
CRP: C reactive protein; Epo: erythropoietin, IU: international units, HDL: high density lipoprotein cholesterol; HFE muts +: positive for HFE mutations; GLM: generalized linear model.

ISSN: 1471-2369