Figure 4From: Indoxyl sulfate, a uremic toxin, downregulates renal expression of Nrf2 through activation of NF-κB Immunohistochemistry of Nrf2, HO-1, NQO1 and 8-OHdG in the kidneys of DN, DN+IS, DH, and DH+IS rats. Nrf2, HO-1 and NQO1 were localized in the cytoplasm of tubular cells, especially in the kidneys of DN rats. 8-OHdG, a marker of ROS, was localized in the nuclei of tubular cells, especially in the kidneys of DH+IS rats.Back to article page