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Figure 5 | BMC Nephrology

Figure 5

From: Indoxyl sulfate, a uremic toxin, downregulates renal expression of Nrf2 through activation of NF-κB

Figure 5

Immunostaining-positive areas of Nrf2, HO-1, NQO1 and 8-OHdG in the kidneys of DN, DN+IS, DH, and DH+IS rats. Immunostaining-positive areas of Nrf2, HO-1 and NQO1 were significantly decreased in DN+IS, DH and DH+IS rats as compared with DN rats. On the other hand, immunostaining-positive area of 8-OHdG was significantly increased in DN+IS, DH and DH+IS rats as compared with DN rats. Data are expressed as mean±SE (n=8). **P < 0.01, ***P < 0.001 vs. DN; ### P<0.001 vs. DH.

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