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Table 1 General clinical and renal histopathological profiles of patients with lupus nephritis at renal biopsy

From: Serum levels and renal deposition of C1q complement component and its antibodies reflect disease activity of lupus nephritis

Number of patients 218 C3 (mean ± SD) (g/l) 0.45 ± 0.23
Gender (male/female) 33/185 Anti-nuclear antibody (ANA) (+) No.(%) 215 (98.6)
Age (mean ± SD) (years) 32.5 ± 11.3 Anti-double stranded DNA antibody (ds-DNA) (+) No.(%) 153 (70.6)
Follow-up time (median, range) (months) 41 (1,360) Anti-SSA antibody (+) No.(%) 102 (46.8)
Fever (non-infectious) No.(%) 69 31.7) Anti-SSB antibody (+) No.(%) 25 (11.5)
Malar rash No.(%) 118 (54.1) Anti-Smith antibody(Sm) (+) No.(%) 53 (24.3)
Photosensitivity No.(%) 47 (21.6) Anti-ribonucleoprotein (RNP) antibody (+) No.(%) 66 (30.3)
Oral ulcer No.(%) 64 (29.4) Anti- cardiolipin antibody (+) No.(%) 16 (7.3)
Alopecia No.(%) 68 (31.2) SLEDAI (mean ± s.d.) 17.6 ± 5.8
Arthralgia No.(%) 115 (52.8) Activity indices (AI) score (median, range) 8 (0,19)
Serositis No.(%) 34 (15.6) Endocapillary hypercellualrity (median, range) 3 (0,-3)
Neurologic disorder No.(%) 14 (6.4) Cellular crescents (median, range) 0 (0,6)
Anemia No.(%) 147 (67.4) Karyorrhexis/fibrinoid necrosis (median, range) 0 (0,6)
Leukocytopenia No.(%) 102 (46.8) Subendothelial hyaline deposits (median, range) 1 (0,3)
Thrombocytopenia No.(%) 64 (29.4) Interstitial inflammatory cell infiltration (median, range) 1 (0,3)
Hematuria No.(%) 168 (77.1) Glomerular leukocyte infiltration (median, range) 1 (0,12)
Leukocyturia (non-infection) No.(%) 118 (54.1) Chronicity indices (CI) score (median, range) 2 (0,10)
Acute renal failure No.(%) 39 (17.9) Glomerular sclerosis (median, range) 0 (0,3)
Hemoglobin (mean ± SD) (g/l) 100.92 ± 26.36 Fibrous crescents (median, range) 0 (0,3)
Urine protein (median, range) (g/24 hours) 4.36 (0–17) Tubular atrophy (median, range) 1 (0,3)
Serum creatinine (median, range) (μmol/l) 82.0 (37,1000) Interstitial fibrosis (median, range) 1 (0,3)
  1. SSA/SSB, Sjögren’s syndrome A/Bantigen; SSB, Sjögren’s syndrome B antigen; SLEDAI, SLE Disease Activity Index.