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Table 2 Associations between presence of anti-C1q autoantibodies, levels of C1q and clinical parameters of patients with lupus nephritis

From: Serum levels and renal deposition of C1q complement component and its antibodies reflect disease activity of lupus nephritis

  Patients with anti-C1q autoantibodies Patients without anti-C1q autoantibodies Pvalue Patients with levels of C1q above 40.97 μg/ml Patients with levels of C1q under 40.97 μg/ml Pvalue
Demographic data
Number of patients (%) 93/218(42.7%) 125/218(57.3%)   75/218(34.4%) 143/218(65.6%)  
Gender (male/female) 14/79 19/106 NS 12/63 21/122 NS
Age (mean ± SD) (years) 31.27 ± 9.96 33.47 ± 11.21 NS 34.15 ± 10.92 31.69 ± 11.40 NS
Clinical and laboratory data
Fever (non-infectious) No.(%) 31(33.3%) 38(30.4%) NS 19(25.3%) 50(35.0%) NS
Malar rash No.(%) 51(54,8%) 67(53,6%) NS 42(56.0%) 76(53.1%) NS
Photosensitivity No.(%) 20(21.5%) 27(21.6%) NS 16(21.3%) 31(21.7%) NS
Oral ulcer No.(%) 28(30.1%) 38(30.4%) NS 20(26.7%) 44(30.8%) NS
Alopecia No.(%) 30(32.3%) 38(30.4%) NS 26(34.7%) 42(29.4%) NS
Arthralgia No.(%) 60(64.5%) 55(44.0%) 0.003 36(45.6%) 79(55.2%) NS
Serositis No.(%) 13(14.0%) 21(16.8%) NS 10(13.3%) 24(16.8%) NS
Neurologic disorder No.(%) 7(7.5%) 7(5.6%) NS 1(1.3%) 13(9.1%) NS
Anemia No.(%) 73(78.5%) 74(59.2%) 0.003 41(54.7%) 106(74.1%) 0.004
Leukocytopenia No.(%) 49(52.7%) 53(42.4%) NS 23(30.7%) 79(55.2%) NS
Thrombocytopenia No.(%) 26(28.0%) 38(30.4%) NS 19(25.3%) 45(31.5%) NS
Hematuria No.(%) 79(36.2%) 89(40.8%) 0.017 51(68.0%) 117(81.8%) 0.021
Leukocyturia No.(%) 55(25.2%) 63(28.9) NS 34(45.3%) 84(58.7%) NS
Acute kidney injury No.(%) 18(8.3%) 21(9.6%) NS 13(17.3%) 26(18.2%) NS
Hemoglobin (mean ± SD.) (g/l) 96.30 ± 25.78 104.36 ± 26.36 0.025 102.89 ± 31.52 99.89 ± 23.27 NS
Urine protein (mean ± SD) (g/24 hours) 4.42 ± 3.05 5.40 ± 3.39 NS 5.64 ± 3.70 4.64 ± 3.00 0.045
C3 (mean ± SD) (g/l) 0.39 ± 0.19 0.50 ± 0.25 <0.001 0.60 ± 0.25 0.37 ± 0.17 <0.001
Anti-nuclear antibody (ANA) (+) No.(%) 92(98.9%) 123(98.4%) NS 73(97.3%) 142(99.3%) NS
Anti-double stranded DNA antibody (ds-DNA) (+) No.(%) 71(76.3%) 82(65.6%) NS 43(57.3%) 110(76.9%) 0.003
Anti-SSA antibody (+) No.(%) 45(48.4%) 57(45.6%) NS 43(57.3%) 59(41.3%) NS
Anti-SSB antibody (+) No.(%) 8(8.6%) 17(13.6%) NS 9(12.0%) 16(11.2%) NS
Anti-Smith antibody(Sm) (+) No.(%) 26(28.0%) 27(21.6%) NS 21(28.0%) 32(22.4%) NS
Anti-ribonucleoprotein (RNP) antibody (+) No.(%) 34(36.7%) 32(25.6%) NS 26(34.7%) 40(28.0%) NS
Anti- cardiolipin antibody (+) No.(%) 10(10.8%) 6(4.8%) NS 2(2.7%) 14(9.8%) NS
SLEDAI 18.72 ± 5.70 16.74 ± 5.69 0.012 15.47 ± 4.90 18.69 ± 5.89 <0.001
  1. NS, no significance.