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Table 4 Multivariable adjusted odd ratios (and 95% confidence intervals) for the determinants of CKD stage 3-5

From: Chronic kidney diseases in mixed ancestry south African populations: prevalence, determinants and concordance between kidney function estimators

Variables MDRD MDRD corrected CKD-EPI CKD-EPI corrected Cockroft-Gault
Age (/year) 1.09 (1.08-1.11) 1.11 (1.09-1.14) 1.14 (1.11-1.15) 1.14 (1.11-1.17) 1.21 (1.18-1.25)
Female gender 2.88 (1.92-4.38) 2.15 (1.18-4.14) 2.15 (1.36-3.47) 1.97 (1.07-3.83) 1.43 (0.84-2.45)
Cohort 0.27 (0.16-0.44) 0.50 (0.21-1.04) 0.39 (0.22-0.68) 0.31 (0.10-0.73) 0.30 (0.14-0.60)
Known hypertension 1.96 (1.35-2.90) 2.42 (1.28-4.94) 1.97 (1.25-3.15) 2.34 (1.20-4.93) 2.76 (1.56-5.00)
Triglycerides (/mmol/L) NS 1.33 (1.04-1.67) NS 1.33 (1.00-1.71) NS
Body mass index (/kg/m2) NS NS NS NS 0.81 (0.77-0.85)
Total cholesterol (/mmol/L) NS NS 1.19 (1.02-1.39) NS NS
  1. CKD-EPI, Chronic Kidney Disease Collaboration Epidemiology; 4-v-MDRD, four variable Modification of Diet in Renal Disease.
  2. For CKD-EPI, TC was only significant when triglycerides (NS) was removed from the model, however triglycerides in the presence of other covariates except total cholesterol was not significant. For Cockroft-Gault: Hip was significant when replacing waist circumference in the models, not in its presence. And hypertension was significant only in the presence of body mass index in the model.