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Table 1 Characteristics and biochemical parameters of the whole cohort and Quartiles: Q1 to Q4 of FGF23

From: Fibroblast growth factor 23, mineral metabolism and mortality among elderly men (Swedish MrOs)

N = 2838

All

Q1

Q2

Q3

Q4

 

N = 2838

N = 709

N = 710

N = 709

N = 710

FGF23 Range (pg/ml)

1.5-800

1.5-32.2

32.4-43.4

43.5-57.4

57.5-800

FGF23 median (IQR)(pg/ml)

43.5 (32.4-57.5)

25.3 (19.2-28.8)

37.9 (35.3-40.4)

49.6 (46.5-53.0)

69.9 (62.7-85.5)

Age (years)

75.5 ± 3.2

75.5 ± 3.1

75.3 ± 3.2

75.5 ± 3.2

75.6 ± 3.2

Weight (kg)

80.6 ± 12.1

77.8 ± 11.3

80.7 ± 12.3*

81.1 ± 11.5*

82.9 ± 12.7*

BMI (kg/m 2 )

26.4 ± 3.6

25.6 ± 3.4

26.4 ± 3.6*

26.5 ± 3.3*

27.0 ± 3.8*

Smoking (%)

8

9

8

8

8

Diabetes (%)

9

7

10*

10*

10*

Hypertension (%)

36

30

33

36*

45*

Prevalent CVD

19

14

19*

19*

24*

eGFR (ml/min/1.73 m 2 )

72.0 ± 20

80.2 ± 18

75.2 ± 18*

71.1 ± 17*

61.5 ± 21*

PTH median IQR (pmol/L)

4.3 (3.0 - 5.8)

3.8 (2.7 - 5.1)

4.2* (3.0 - 5.8)

4.3* (3.0 - 5.8)

4.7* (3.2 - 6.4)

Pi (mmol/L)

1.07 ± 0.16

1.08 ± 0.16

1.06 ± 0.17*

1.07 ± 0.16

1.08 ± 0.16

Ca (mmol/L)

2.36 ± 0.16

2.39 ± 0.17

2.33 ± 0.16*

2.34 ± 0.14*

2.36 ± 0.15

Albumin (g/L)

43.1 ± 3.6

43.4 ± 3.7

43.5 ± 3.6

42.9 ± 3.6*

42.8 ± 3.5*

25OHvitD (nmol/L)

69.8 ± 23.6

70.6 ± 23.1

67.9 ± 23.3*

68.5 ± 22.4

72.2 ± 25.3

Mortality rate/1000 py (95%CI)

27.7 (24.9 - 30.7)

26.3 (20.8 - 31.8)

26.1 (20.6 - 31.7)

24.7 (19.2 - 30.1)

34.0 (27.9 - 41.0)

Cardiovascular deaths/1000 py (95%CI)

10.3 (8.5 - 12.0)

7.1 (4.3- 9.9)

12.2 (8.4- 15.9)

8.4 (5.2 - 11.6)

13.6 (9.5 - 17.8)

  1. Descriptive statistics of the whole cohort and quartiles. IQR means interquartile range and is expressed as border for lowest quartile to highest quartile. BMI means body mass index and is calculated as weight in kg/(length in m) 2. CVD is cardiovascular disease, including coronary artery disease and stroke. * means differ from Q1, analysed by ANOVA for continuous normally distributed variables and by Kruskall-Wallis test for the others. P < 0.05 was considered significant.