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Table 5 Cox regression models of parameters of mineral metabolism in sub-cohort with eGFR > 60 (N = 2075)

From: Fibroblast growth factor 23, mineral metabolism and mortality among elderly men (Swedish MrOs)

Factors

Model 1 age

Model 2 age eGFR, phosphate

Model 3 age, BMI, eGFR, albumin, calcium, phosphate, (PTH, FGF23 or 25D as appropriate), smoking, diabetes, hypertension, prevalent cancer, prevalent CVD

Mortality HR (95% CI)

   

Log10FGF23/(1 - SD)

1.02

1.02

1.02

(0.88 - 1.19)

(0.87 - 1.18)

(0.86 - 1.20)

Log10PTH/(1 - SD)

1.08

1.11

1.05

(0.93 - 1.28)

(0.94 - 1.31)

(0.88 - 1.24)

25D/10 nmol/L

0.88

0.86

0.83

(0.78 - 0.98)

(0.78 - 95)

(0.70 - 0.96)

Cardiovascular mortality HR (95% CI)

   

Log10FGF23/(1-SD)

1.45*

1.44*

1.55*

(1.11 - 1.89)

(1.09 - 1.89)

(1.13 - 2.11)

Log10PTH/(1-SD)

1.16

1.14

0.98

(0.87 - 1.53)

(0.87 - 1.52)

(0.74 - 1.30)

25D/10 nmol/L

0.88*

0.88*

0.89

(0.77 - 0.99)

(0.77 - 0.99)

(0.78 - 1.01)

Cox Hazards regression models of CVD-related death and parameters of mineral metabolism in the sub-cohort without prevalent cardiovascular disease

No prevalent CVD (N = 2324)

  

CVD mortality

HR (95% CI)

Log10FGF23/(1-SD)

1.37*

1.29

1.28

(1.06 - 1.77)

(0.98 - 1.71)

(0.95 - 1.72)

Log10PTH/(1-SD)

1.16

1.11

1.10

(0.89 - 1.52)

(0.85 - 1.44)

(0.85 - 1.43)

25D/10 nmol/L

0.92

0.92

0.94

 

(0.82 - 1.03)

(0.82 - 1.03)

(0.84 - 1.05)