From: Fibroblast growth factor 23, mineral metabolism and mortality among elderly men (Swedish MrOs)
Factors | Model 1 age | Model 2 age eGFR, phosphate | Model 3 age, BMI, eGFR, albumin, calcium, phosphate, (PTH, FGF23 or 25D as appropriate), smoking, diabetes, hypertension, prevalent cancer, prevalent CVD |
---|---|---|---|
Mortality HR (95% CI) | |||
Log10FGF23/(1 - SD) | 1.02 | 1.02 | 1.02 |
(0.88 - 1.19) | (0.87 - 1.18) | (0.86 - 1.20) | |
Log10PTH/(1 - SD) | 1.08 | 1.11 | 1.05 |
(0.93 - 1.28) | (0.94 - 1.31) | (0.88 - 1.24) | |
25D/10 nmol/L | 0.88 | 0.86 | 0.83 |
(0.78 - 0.98) | (0.78 - 95) | (0.70 - 0.96) | |
Cardiovascular mortality HR (95% CI) | |||
Log10FGF23/(1-SD) | 1.45* | 1.44* | 1.55* |
(1.11 - 1.89) | (1.09 - 1.89) | (1.13 - 2.11) | |
Log10PTH/(1-SD) | 1.16 | 1.14 | 0.98 |
(0.87 - 1.53) | (0.87 - 1.52) | (0.74 - 1.30) | |
25D/10 nmol/L | 0.88* | 0.88* | 0.89 |
(0.77 - 0.99) | (0.77 - 0.99) | (0.78 - 1.01) | |
Cox Hazards regression models of CVD-related death and parameters of mineral metabolism in the sub-cohort without prevalent cardiovascular disease | |||
No prevalent CVD (N = 2324) | |||
CVD mortality | |||
HR (95% CI) | |||
Log10FGF23/(1-SD) | 1.37* | 1.29 | 1.28 |
(1.06 - 1.77) | (0.98 - 1.71) | (0.95 - 1.72) | |
Log10PTH/(1-SD) | 1.16 | 1.11 | 1.10 |
(0.89 - 1.52) | (0.85 - 1.44) | (0.85 - 1.43) | |
25D/10 nmol/L | 0.92 | 0.92 | 0.94 |
(0.82 - 1.03) | (0.82 - 1.03) | (0.84 - 1.05) |