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Table 4 Association between blood pressure (BP) categories and eGFR <60 mL/min/1.73 m 2 in Indian population

From: Ethnic differences in the association between blood pressure components and chronic kidney disease in middle aged and older Asian adults

BP categories No. at risk (cases) Prevalence of eGFR <60 mL/min/1.73 m2(%) Age, sex-adjusted OR (95% CI) Multivariable model 1* OR (95% CI) Multivariable model 2† OR (95% CI)
JNC-7 BP category‡      
   Normal 532 (12) 2.3 1.00 (referent) 1.00 (referent) -
   Prehypertension 834 (24) 2.9 0.98 (0.48-2.00) 0.87 (0.42-1.78)  
   Stage1 hypertension 1052 (122) 11.6 2.98 (1.60-5.54) 2.40 (1.28-4.51)  
   Stage 2 hypertension 810 (106) 13.1 2.63 (1.40-4.95) 1.98 (1.04-3.78)  
   P trend   8.2 <0.0001 0.002  
Hypertensive status      
   Normotensive 1366 (36) 2.6 1.00 (referent) 1.00 (referent) -
   Hypertensive 1862 (228) 12.2 2.86 (1.97-4.16) 2.43 (1.66-3.57)  
Systolic BP quartiles      
   Quartile 1 (79–121 mm Hg) 825 (42) 5.1 1.00 (referent) 1.00 (referent) 1.00 (referent)
   Quartile 2 (122–133 mm Hg) 782 (64) 8.2 1.19 (0.78-1.82) 1.11 (0.73-1.71) 1.06 (0.69-1.64)
   Quartile 3 (134–147 mm Hg) 817 (54) 6.6 0.76 (0.49-1.18) 0.68 (0.44-1.07) 0.61 (0.39-0.96)
   Quartile 4 (148–237 mm Hg) 804 (104) 13.0 1.24 (0.83-1.84) 1.06 (0.71-1.59) 0.96 (0.64-1.45)
   P trend    0.5 0.9 0.5
Each 10 units increase in systolic BP    1.00 (0.94-1.08) 0.98 (0.91-1.05) 0.97 (0.90-1.04)
Diastolic BP quartiles      
   Quartile 1 (43–69 mm Hg) 810 (102) 12.6 1.00 (referent) 1.00 (referent) 1.00 (referent)
   Quartile 2 (70–76 mm Hg) 803 (72) 9.0 0.69 (0.49-0.96) 0.74 (0.51-1.06) 0.81 (0.56-1.16)
   Quartile 3 (77–83 mm Hg) 786 (52) 6.6 0.55 (0.38-0.79) 0.64 (0.42-0.97) 0.78 (0.52-1.17)
   Quartile 4 (84–136 mm Hg) 829 (38) 4.6 0.42 (0.28-0.63) 0.54 (0.32-0.90) 0.71 (0.45-1.13)
   P trend    <0.0001 0.01 0.1
Each 10 units increase in diastolic BP    0.67 (0.58-0.79) 0.71 (0.58-0.88) 0.83 (0.70-1.00)
Pulse pressure quartiles      
   Quartile 1 (23–45 mm Hg) 804 (23) 2.9 1.00 (Referent) 1.00 (Referent) 1.00 (referent)
   Quartile 2 (46–55 mm Hg) 768 (45) 5.9 1.53 (0.89-2.57) 1.42 (0.83-2.42) 1.40 (0.82-2.41)
   Quartile 3 (56–67 mm Hg) 846 (72) 8.5 1.62 (0.98-2.68) 1.35 (0.81-2.25) 1.22 (0.72-2.04)
   Quartile 4 (68–121 mm hg) 810 (124) 15.3 2.15 (1.31-3.52) 1.66 (1.00-2.76) 1.46 (0.87-2.43)
   P trend    0.002 0.07 0.2
Each 10 units increase in pulse pressure    1.15 (1.06-1.25) 1.09 (1.00-1.19) 1.06 (0.97-1.16)
  1. Abbreviations: eGFR, estimated glomerular filtration rate; OR, odds ratio; CI, confidence interval.
  2. * Adjusted for age (years), gender, education (primary and below, high school and above), body mass index (kg/m2), smoking (current, former, never), alcohol intake (present, absent), diabetes status (present, absent).
  3. † Adjusted for variables in model 1 + antihypertensive medication use.
  4. ‡ BP classified according to Seventh Report of the Joint National Committee (JNC 7) on Prevention, Detection, Evaluation, and
  5. Treatment of High Blood Pressure criteria (normal, systolic BP <120 mm Hg and diastolic BP <80 mm Hg; prehypertension,
  6. systolic BP 120–139 or diastolic BP 80–89 mm Hg; stage 1 hypertension, systolic BP 140–159 or diastolic BP 90–99 mm Hg;
  7. stage 2 hypertension, systolic BP ≥160 or diastolic BP ≥100 mm Hg).
  8. Hypertension was defined as a self-reported current use of antihypertensive medication or systolic BP ≥140 mm Hg or diastolic BP ≥90 mm Hg.