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Table 1 Overview of accepted publications

From: Is there an association between elevated or low serum levels of phosphorus, parathyroid hormone, and calcium and mortality in patients with end stage renal disease? A meta-analysis

Author, year Study or database name Study design Duration of follow-up Dialysis vintage Dialysis type Sample size Allowed for non-linear relationship?* Was the biochemical parameter associated with mortality after multivariate adjustment? Graphical depiction?
PTH Phosphorus Calcium
Studies with adequate data for meta-analysis
Block 2004 [10] Fresenius Medical Care Retrospective cohort 12-18 months (total) Maintenance HD 40,538 Yes Yes Yes Yes Yes (U-shaped for calcium, linear for albumin-adjusted calcium)
Dukkipati 2010 [29] DaVita-NIED Prospective cohort 63 months (total) Maintenance HD 748 Yes (for PTH only) Yes Not stated Not stated No
Floege 2011 [16] European Fresenius Medical Care Retrospective cohort 20.9 months (median) Incident or Maintenance HD 7,970 Yes (also used fractional polynomials) Yes Yes Yes Yes
Kalantar-Zadeh 2006 [14] DaVita Prospective cohort 24 months (total) Maintenance HD 58,058 Yes Yes Yes Yes Yes
Rodriguez-Benot 2005 [24] Cordoba, Spain Prospective cohort 97.6 months (median) Maintenance HD 385 Yes (for phosphorus and PTH only) No Yes Yes No
Tangri 2011 [30] UKRR Prospective cohort 24 months (total) Incident HD, PD 7,076 Yes Yes Yes Yes No
Tentori 2008 [15] Dialysis Clinic Inc. Prospective cohort 16.4 months (median) Maintenance HD 25,588 Yes Yes Yes Yes Yes
Studies that did not qualify for meta-analysis
Block 1998 [31] USRDS (CMAS and DMMS-1) Retrospective cohort 2 years Maintenance HD 6,407 Yes (also analyzed as continuous linear predictor) No Yes Yes (text and figure are inconsistent) Yes (J-shaped for phosphorus, linear for calcium and PTH)
Block 2010 [32] DaVita, CMS-ESRD Prospective cohort 2.2 years Maintenance HD 25,150 Yes Yes Yes Yes No
Chang 2006 [33] VA Cooperative Study #440 Post-hoc RCT 4 years Incident or Maintenance HD 197 Yes No Not measured Not measured No
Dreschler 2011 [34] NECOSAD Prospective cohort 6 years Incident HD, PD 1,628 Yes (for PTH only) Yes Not stated Not stated No
Dreschler 2011 [35] NECOSAD Prospective cohort 3 years Incident HD, PD 762 No Not stated Not stated Not stated No
Etter 2010[36] monitor! Prospective cohort 562 days (median) Maintenance HD 170 No No Not measured Not measured No
Foley 1996 [37] Royal Victoria Hospital Prospective cohort 5 years Incident HD, PD 433 Yes (calcium and phosphorus were binary) Not measured No Yes No
Ganesh 2001 [7] USRDS (CMAS and DMMS 1/3/4) Retrospective cohort 2 years Maintenance HD 12,833 Yes Yes Yes Not stated Yes (U-shaped for PTH)
Gutierrez 2008 [38] ArMORR (Fresenius) Prospective cohort 1 year Incident HD 10,044 Yes (for phosphorus only) Not stated Yes Not stated No
Hakemi 2010 [39] Tehran, Iran Prospective cohort 18.4 months (mean) Maintenance PD 282 Yes (for calcium and PTH only, binary) Yes Not measured Yes No
Hsiao 2011 [40] Chang Gung Memorial Hospital Prospective cohort 1 year Maintenance HD 109 No No No Yes No
Isakova 2009 [41] ArMORR (Fresenius) Prospective cohort 1 year Incident HD 10,044 Yes (for phosphorus only) Not stated Yes Not stated No
Jassal 1996 [42] Belfast City Hospital Prospective cohort 1 year Incident NR 99 No Not measured Yes (but not on older subset of patients) Not measured No
Jean 2009 [43] Tassin la Demi-lune, France Prospective cohort 2 years Maintenance HD 219 Yes (for phosphorus only, Not stated for PTH and calcium) Not stated No Not stated No
Kalantar-Zadeh 2010 [44] DaVita-Los Angeles Prospective cohort 5 years Incident or Maintenance HD 139,328 Yes Yes Yes Yes Yes (except for PTH)
Kimata 2007 [45] DOPPS 1/2 (Japan) Retrospective cohort 8,056 patient-years Maintenance HD 3,973 Yes (also analyzed as continuous linear predictors) Yes, when linear No, when categorical Yes, when categorical No, when linear Yes, for both categorical and linear Yes for phosphorus No for calcium or PTH
Komaba 2008 [46] Takasago, Japan Retrospective cohort 45 months Maintenance HD 99 Yes (binary only) No Yes (but analyzed with calcium only) Yes (but analyzed with phosphorus only) No
Lacson 2009 [47] Fresenius Knowledge Center Retrospective cohort 1 year Maintenance HD 78,420 In some models Yes Yes Yes Yes
Leggat 1998 [48] USRDS (CMAS and DMMS) Retrospective cohort 2 years Maintenance HD 6,251 Yes Not measured Yes Not measured No
Lin 2010 [49] Chang Gung Memorial Hospital Prospective cohort 18 months Maintenance PD 315 No No No No No
Lowrie 1990 [50] National Medical Care Cross-sectional 18 months Maintenance HD 19,746 No Not measured Yes No No
Lukowski 2010 [51] DaVita Retrospective cohort 3 years Maintenance HD 58,917 Yes (for phosphorus only, Not stated for PTH and calcium) Not stated Yes Not stated Yes for phosphorus No for calcium or PTH
Maeda 2009 [52] Kyushu University Hospital Prospective cohort 5 years Maintenance HD 226 No No No No No
McNeill 2010 [53] DaVita Cohort, unspecified 3 years Maintenance HD 58,917 Yes (for PTH only, Not stated for phosphorus and calcium) Yes Not stated Not stated Yes for PTH No for calcium or phosphorus
Melamed 2006 [54] CHOICE Prospective cohort 2.5 years (median) Incident HD, PD 1,007 Yes Yes (as a time-dependent predictor) Yes (as a time-dependent predictor) Yes (as a time-dependent predictor) No
Miller 2010 [22] DaVita-Los Angeles Retrospective cohort 5 years Maintenance HD 107,200 Yes Yes Yes Yes Yes for calcium No for phosphorus or PTH
Miller 2009 [55] DaVita Cohort, unspecified 5 years Maintenance HD 151,555 Yes Yes Yes Yes No
Morrone 2009 [56] MMTE (Italy) Prospective cohort 18.8 months (mean) Incident HD 411 Yes Yes Not stated Not stated Yes for PTH No for phosphorus or calcium
Naves-Diaz 2011 [57] Fresenius-CORES Retrospective cohort 4.5 years Incident or Maintenance HD 16,173 Yes Yes Yes Yes Yes
Naves-Diaz 2008 [58] Fresenius-CORES Retrospective cohort 4.5 years Incident or Maintenance HD 16,004 Yes Yes Yes Yes No
Noordzij 2008 [26] NECOSAD Prospective cohort 7.8 years Incident HD, PD 1,621 Yes (restricted cubic splines) Not stated Yes Yes Yes (spline)
Noordzij 2005 [23] NECOSAD Prospective cohort 7.5 years (max) Incident HD, PD 1,629 Yes No Yes No No
Phelan 2008 [59] Beaumon Hospital (Ireland) Retrospective cohort 4.5 years (mean) Incident HD, PD 1,007 Yes (binary only) No Yes No No
Port 2004 [60] DOPPS I Prospective cohort 5 years Maintenance HD 17,245 Yes (for phosphorus only, binary) Not measured Yes Not measured No
Saran 2003 [61] DOPPS Retrospective cohort 1.8-2.9 years (median, depending on region) Maintenance HD 14,930 Yes (for phosphorus only, binary) No Yes Not measured No
Shinaberger 2008 [20] DaVita Retrospective cohort 3 years Maintenance HD 30,075 Yes (restricted cubic splines) Not stated Yes Not stated Yes
Shinaberger 2008 [21] DaVita Retrospective cohort 3 years Maintenance HD 34,307 Yes (restricted cubic splines, PTH only) Yes Not stated Not stated Yes
Simic-Ogrizovic 2009 [62] Clinical Center of Serbia Prospective cohort 3 years Maintenance HD 130 No Not measured Yes No No
Sit 2008 [63] Dicle University Retrospective cohort 10 years Maintenance NR 1,538 No Yes No No No
Slinin 2005 [5] USRDS (1/2/3) Retrospective cohort 3.9 years (mean) Maintenance HD 14,829 Yes Yes Yes Yes No
Stevens 2004 [25] PROMIS Prospective cohort 2.6 years (median) Maintenance HD, PD 515 Yes (examined interactions; also modeled continuous, linear predictors) No, when continuous Yes, when categorical with interactions Yes, for both continuous and categorical with interactions No, when continuous Yes, when categorical with interactions No
Takemoto 2009 [64] Toranomon Hospital Prospective cohort 8 years Maintenance HD 68 No Yes No No No
Wald 2008 [65] HEMO Post-hoc RCT 6.5 years Maintenance HD 1,846 Yes No Yes Yes Yes for calcium and phosphorus No for PTH
Young 2004 [66] DOPPS 1/2 Retrospective cohort 2 years Maintenance HD 15,475 No Yes Yes Yes No
  1. HD, hemodialysis; NR, not reported; PD, peritoneal dialysis; PTH, parathyroid hormone; RCT, randomized controlled trial.
  2. * Study explicitly allowed for a non-linear relationship between biochemical parameters and mortality (eg, use of a categorical variable or splines).
  3. †Study provided a graphical depiction of the relationship between biochemical parameters and mortality.