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Table 4 Mortality risk for relatively low biochemical parameter values versus referent values

From: Is there an association between elevated or low serum levels of phosphorus, parathyroid hormone, and calcium and mortality in patients with end stage renal disease? A meta-analysis

Study

Reference range

N*

RR for low values vs. referent (95% CI)

Follow-up (months)†

Phosphorus (mg/dL)

Block 2004 [10]

4.0-5.0

13,478

1.01 (0.95-1.08)

18

Kalantar-Zadeh 2006 [14]

5.0-6.0

34,636

0.99 (0.88-1.12)

24

Rodriguez-Benot 2005 [24]

3.0-5.0

170

0.41 (0.05-3.26)

97.6

Tangri 2011 [30]

3.5-5.5

4,776

1.22 (1.01-1.49)

24

Calcium (mg/dL)

Block 2004 [10]

9.0-9.5

28,129

0.81 (0.77-0.85)

30

Kalantar-Zadeh 2006 [14]

9.0-9.5

37,662

0.93 (0.87-0.98)

24

Tangri 2011 [30]

8.4-9.5

3,394

1.35 (0.24-7.48)

24

Parathyroid hormone (pg/mL)

Dukkipati 2010 [29]

300-600

648

0.72 (0.52-0.95)

63

Floege 2010 [16]

150-300

2,595

1.31 (1.14-1.51)

20.9

Kalantar-Zadeh 2006 [14]

200-300

33,758

0.99 (0.94-1.05)

24

Tangri 2011 [30]

151-300

5,071

0.84 (0.61-1.16)

24

Tentori 2008 [15]

100-300

17,648

1.00 (0.93-1.08)

18.7

  1. CI, confidence interval; RR, risk ratio.
  2. *Sample size includes patients in the reference range plus those with relatively low biochemical parameter values.
  3. †The median or mean (or total, if median was not given) follow-up time in each study.