Figure 2
Course of total calcium (A), ionised calcium (B) and total to ionised calcium ratio (C) during treatment by continuous venovenous haemofiltration in patients with and without citrate accumulation. Patients with accumulation were converted to continuous venovenous haemofiltration with bicarbonate-based replacement solution without anticoagulation after a mean time of 13.0 ± 8.7 h. The differences between the groups reached significance at several time points (*P =0.05 or lower) with higher ionized calcium concentrations in patients with citrate accumulation after switching from citrate to bicarbonate-based replacement fluid (with ionized calcium concentration of 1.75 mmol/l), while the overall course of these calcium parameters was similar (P = 0.21 for total calcium, P = 0.92 for ionised calcium and P = 0.08 for total to ionised calcium ratio). Mean ± SD.