Table 3 Univariate hazard ratios for renal progression and all-cause mortality according to eGFR levels
Renal progression | All-cause mortality | |||||||
|---|---|---|---|---|---|---|---|---|
eGFR ≥45 mL/min/1.73 m2 | eGFR <45 mL/min/1.73 m2 | eGFR ≥45 mL/min/1.73 m2 | eGFR <45 mL/min/1.73 m2 | |||||
Variable | HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p |
Age | 1.04 (0.93 - 1.09) | 0.18 | 0.98 (0.97 - 0.99) | <0.001 | 1.13 (1.05 - 1.22) | 0.002 | 1.06 (1.04 - 1.08) | <0.001 |
Male gender | 1.05 (0.28 - 3.93) | 0.948 | 0.75 (0.59 - 0.94) | 0.015 | 0.57 (0.16 - 2.02) | 0.38 | 0.75 (0.52 - 1.09) | 0.139 |
Diabetes (yes vs. no) | 4.89 (1.22 - 9.61) | 0.025 | 1.88 (1.47 - 2.42) | <0.001 | 1.08 (0.28 - 4.18) | 0.91 | 1.36 (0.93 - 1.99) | 0.118 |
Hypertension (yes vs. no) | 3.34 (0.62 - 18.14) | 0.274 | 1.34 (0.87 - 2.08) | 0.189 | 3.41 (0.10 - 11.34) | 0.234 | 0.82 (0.46 - 1.47) | 0.503 |
Hypercholesterolemia (yes vs. no) | 0.61 (0.16 - 2.29) | 0.464 | 1.06 (0.83 - 1.35) | 0.641 | 0.55 (0.15 - 1.97) | 0.361 | 0.79 (0.55 - 1.16) | 0.234 |
Smoking (yes vs. no) | 6.15 (1.27 - 9.82) | 0.024 | 0.95 (0.74 - 1.22) | 0.679 | 2.67 (0.75 - 9.51) | 0.13 | 0.95 (0.64 - 1.41) | 0.789 |
Obesity (yes vs. no) | 0.89 (0.11 - 6.98) | 0.858 | 1.17 (0.84 - 1.62) | 0.354 | 1.46 (0.31 - 6.87) | 0.635 | 0.65 (0.34 - 1.25) | 0.195 |
Hyperphosphatemia (yes vs. no) | 0.13 (0.02 - 1.06) | 0.057 | 4.27 (3.29 - 5.53) | <0.001 | 0.31 (0.07 - 1.49) | 0.143 | 1.39 (0.95 - 2.05) | 0.088 |
Hyperparathyroidism (yes vs. no) | 0.69 (0.08 - 5.58) | 0.725 | 2.69 (2.31 - 3.57) | <0.001 | 2.12 (0.27 - 16.75) | 0.477 | 2.01 (1.32 - 3.04) | 0.001 |
Anemia (yes vs. no) | 1.15 (0.37 - 6.22) | 0.567 | 11.9 (5.33 - 26.8) | <0.001 | 2.22 (0.62 - 7.71) | 0.225 | 2.63 (1.37 - 5.05) | 0.004 |
Hyperuricemia (yes vs. no) | 0.04 (0.01 - 1.82) | 0.563 | 0.87 (0.67 - 1.11) | 0.266 | 2.45 (0.52 - 11.55) | 0.258 | 1.99 (1.37 - 2.92) | <0.001 |
Hyperkalemia (yes vs. no) | 3.78 (0.47 - 30.7) | 0.214 | 1.69 (1.31 - 2.19) | <0.001 | 3.16 (0.39 - 25.05) | 0.276 | 1.11 (0.71 - 1.74) | 0.649 |
Hypoalbuminemia (yes vs. no) | 5.02 (1.01 - 7.42) | 0.004 | 4.02 (3.16 - 5.12) | <0.001 | 4.79 (1.38 - 6.51) | 0.013 | 3.56 (2.43 - 5.22) | <0.001 |
Acidosis (yes vs. no) | 0.49 (0.01 - 1.01) | 0.756 | 3.35 (2.64 - 4.26) | <0.001 | 5.18 (0.64 - 42.12) | 0.124 | 1.72 (1.17 - 2.53) | 0.006 |
Microinflammation (yes vs. no) | 2.43 (0.49 - 12.1) | 0.276 | 1.33 (1.03 - 1.71) | 0.03 | 4.82 (1.36 - 7.10) | 0.015 | 1.35 (0.89 - 2.03) | 0.148 |
CVD (yes vs. no) | 2.81 (2.61 - 18.2) | 0.004 | 4.56 (2.25 - 9.27) | <0.001 | 0.05 (0.01 - 20.33) | 0.695 | 2.22 (1.35 - 3.64) | 0.002 |
Metabolic complications (≥3 vs. <3) | 1.54 (0.19 - 12.5) | 0.688 | 5.62 (3.80 - 8.32) | <0.001 | 1.25 (0.16 - 9.48) | 0.835 | 4.35 (2.47 - 7.63) | <0.001 |