Figure 3From: Effect of vasopressin antagonism on renal handling of sodium and water and central and brachial blood pressure during inhibition of the nitric oxide system in healthy subjects Effect of tolvaptan on bBP during inhibition of the NO system. Values are mean ± SEM. Baseline brachial blood pressure (bBP) was defined as a mean of the four measurements 30 min prior to L-NMMA infusion. A stable bBP was achieved for the last 40 min of L-NMMA infusion. A mean of the six measurements from last 40 minutes of L-NMMA infusion was used to calculate changes from baseline. Post-hoc Bonferoni test was used for comparison of the mean of the last 40 min of infusion vs. baseline (p = 0.011 in placebo vs p < 0.0001 in tolvaptan). Paired t-test was performed for comparison of the last 40 min of infusion vs. baseline between treatment groups.Back to article page