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Table 1 Urine output (UO), free water clearance (C H2O ), urinary excretion of AQP2 (u-AQP2), ENaC (u- ENaC γ ), sodium (u-Na) and potassium (u-K) during a 24-hours urine collection before each examination day in a randomized, placebo-controlled, double-blind, crossover study of 19 healthy subjects

From: Effect of vasopressin antagonism on renal handling of sodium and water and central and brachial blood pressure during inhibition of the nitric oxide system in healthy subjects

  Before each examination day p (pairedt-test)
Placebo Tolvaptan
UO (ml/24 h) 1969 ± 448 2025 ± 514 0.51
C H2O (ml/min) -0.46 ± 0.61 -0.47 ± 0.57 0.99
U-AQP2 (ng/min) 1.10 ± 0.32 1.12 ± 0.27 0.57
U-ENaCγ (pg/min) 716 ± 374 705 ± 376 0.87
U-Na (mmol/24 h) 103 ± 11 101 ± 8 0.652
U-K (mmol/24 h) 55 ± 19 51 ± 14 0.472
  1. Data are shown as means with ± SD. Paired t-test was used for comparison between groups.