Skip to main content

Table 1 Urine output (UO), free water clearance (C H2O ), urinary excretion of AQP2 (u-AQP2), ENaC (u- ENaC Îł ), sodium (u-Na) and potassium (u-K) during a 24-hours urine collection before each examination day in a randomized, placebo-controlled, double-blind, crossover study of 19 healthy subjects

From: Effect of vasopressin antagonism on renal handling of sodium and water and central and brachial blood pressure during inhibition of the nitric oxide system in healthy subjects

 

Before each examination day

p (pairedt-test)

Placebo

Tolvaptan

UO (ml/24 h)

1969 ± 448

2025 ± 514

0.51

C H2O (ml/min)

-0.46 ± 0.61

-0.47 ± 0.57

0.99

U-AQP2 (ng/min)

1.10 ± 0.32

1.12 ± 0.27

0.57

U-ENaCÎł (pg/min)

716 ± 374

705 ± 376

0.87

U-Na (mmol/24 h)

103 ± 11

101 ± 8

0.652

U-K (mmol/24 h)

55 ± 19

51 ± 14

0.472

  1. Data are shown as means with ± SD. Paired t-test was used for comparison between groups.