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Figure 3 | BMC Nephrology

Figure 3

From: Abnormal urinary excretion of NKCC2 and AQP2 in response to hypertonic saline in chronic kidney disease: an intervention study in patients with chronic kidney disease and healthy controls

Figure 3

Effects of 3% hypertonic saline on urinary excretion of A) AQP2, B) ENaCγ and C) NKCC2 in 20 patients with CKD and 21 healthy controls, and (D-F) u-AQP2, u-ENaCγ and u-NKCC2 in 20 patients classified according to GFR in CKD stage IV (n = 11) and CKD stage III (n = 9). A-C: General linear model (GLM-RM) did not show any difference in u-AQP2 or u-ENaCγ but there was a significant difference in u-NKCC2. Values of u-AQP2 and u-NKCC2 are means ± SEM, u-ENaCγ is median with 25th and 75th percentiles. Paired t-test was used to test for differences between post-infusion to baseline. *p < 0.001; **p < 0.0001. D-F: Independent samples t-test showed a significant difference between CKD stage IV vs. stage III in u-AQP2 and u-NKCC2. Values are medians with 2.5th and 97.5th percentiles. *p < 0.05; **p < 0.0001.

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BMC Nephrology

ISSN: 1471-2369

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