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Figure 4 | BMC Nephrology

Figure 4

From: Abnormal urinary excretion of NKCC2 and AQP2 in response to hypertonic saline in chronic kidney disease: an intervention study in patients with chronic kidney disease and healthy controls

Figure 4

Effects of 3% hypertonic saline on (A) Urine output, (B) Urine osmolality, (C) Free water clearance, (D) 51 Cr-EDTA-clearance, (E) FE Na and (F) FE K in 20 patients with CKD and 21 healthy controls. Values of 51Cr-EDTA-clearance, UO, u-osm, CH2O and FENa are means ± SEM. FEK is median with 25th and 75th percentiles. A-C: General linear model (GLM) with repeated measures was significant in both OU, u-osm and CH2O. D:PGLM-RM between groups was significant. There was a significant response to hypertonic saline as GFR decreased in healthy controls, but increased in CKD patients E-F: PGLM-RM were not significant in FENa and FEK, indicating that the response to 3% saline were similar between groups. Independent-samples t-test or Man Whitney U test in CKD patients vs. controls *p = 0.01, **p < 0.0001

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