Table 4 Post-operative biomarker values for patients adjudicated to PRA and ATN
From: Adjudication of etiology of acute kidney injury: experience from the TRIBE-AKI multi-center study
Biomarkers | Pre-renal azotemia (N = 13) | Acute tubular necrosis (N = 41) | p-value Wilcoxon |
|---|---|---|---|
Urine NGAL | Â | Â | Â |
Pre-op | 34 (41) | 42 (79) | 0.33 |
Day 1 0-6Â hr | 74 (169) | 173 (617) | 0.73 |
Day 1 6-12Â hr | 328 (978) | 50 (68) | 0.81 |
Day 1 12-18Â hr | 85 (108) | 76 (105) | 0.90 |
Day 2 | 81 (79) | 95 (132) | 0.77 |
Day 3 | 57 (72) | 91 (112) | 0.17 |
Day 4 | 110 (124) | 102 (110) | 0.97 |
Day 5 | 60 (72) | 103 (164) | 0.34 |
Urine IL-18 | Â | Â | Â |
Pre-op | 28 (26) | 63 (263.93) | 0.49 |
Day 1 0-6Â hr | 68 (108) | 147.13 (517.98) | 0.39 |
Day 1 6-12Â hr | 249 (640) | 168.01 (416.33) | 0.85 |
Day 1 12-18Â hr | 77 (37) | 211.72 (328.66) | 0.24 |
Day 2 | 91 (55) | 186.03 (298.02) | 0.79 |
Day 3 | 108 (166) | 103.42 (191.36) | 0.72 |
Day 4 | 46 (43) | 73.07 (107.88) | 0.83 |
Day 5 | 25 (20) | 42.79 (77.48) | 0.85 |
Urine KIM 1 | Â | Â | Â |
Pre-op | 3.8 (6.2) | 3.0 (6.7) | 0.73 |
Day 1 0-6Â hr | 1.7 (2.5) | 1.7 (2.6) | 0.57 |
Day 1 6-12Â hr | 2.7 (3) | 2.4 (1.7) | 0.62 |
Day 2 | 9.1 (4.9) | 5.4 (4.0) | 0.01 |
Day 3 | 14.8 (9.5) | 12.4 (11.7) | 0.28 |
Day 4 | 9.2 (9.0) | 9.0 (9.7) | 0.97 |
Day 5 | 4.5 (3.4) | 6.2 (8.6) | 0.96 |
Urine LFABP | Â | Â | Â |
Pre-op | 33 (57) | 27 (86) | 0.77 |
Day 1 0-6Â hr | 68 (65) | 118 (156) | 0.66 |
Day 1 6-12Â hr | 84 (157) | 97 (141) | 0.29 |
Day 2 | 63 (111) | 75 (125) | 0.95 |
Day 3 | 64 (116) | 52 (92) | 0.69 |
Day 4 | 126 (173) | 98 (140) | 0.71 |
Day 5 | 92 (134) | 79 (126) | 0.52 |
Urine Cystatin C | Â | Â | Â |
Pre-op | 0.24 (0.18) | 0.27 (0.39) | 0.54 |
Day 1 0-6Â hr | 0.20 (0.13) | 0.22 (0.13) | 0.81 |
Day 1 6-12Â hr | 0.27 (0.21) | 0.21 (0.13) | 0.40 |
Day 2 | 0.25 (0.17) | 0.26 (0.22) | 0.85 |
Day 3 | 1.12 (2.65) | 0.42 (0.94) | 0.42 |
Day 4 | 1.94 (3.46) | 0.57 (1.07) | 0.63 |
Day 5 | 1.63 (3.12) | 1.14 (3.22) | 0.77 |
Urine Albumin | Â | Â | Â |
Pre-op | 175 (379) | 133 (287) | 0.89 |
Day 1 0-6Â hr | 35 (36) | 56 (109) | 0.5 |
Day 1 6-12Â hr | 48 (77) | 47 (55) | 0.39 |
Day 1 12-18Â hr | 77 (154) | 95 (143) | 0.42 |
Day 2 | 72 (136) | 71 (84) | 0.26 |
Day 3 | 107 (168) | 77 (77) | 0.84 |
Urine ACR | Â | Â | Â |
Pre-op | 0.27 (0.74) | 0.16 (0.3) | 0.94 |
Day 1 0-6Â hr | 0.21 (0.19) | 0.15 (0.17) | 0.32 |
Day 1 6-12Â hr | 0.11 (0.18) | 0.09 (0.13) | 0.64 |
Day 1 12-18Â hr | 0.07 (0.1) | 0.11 (0.16) | 0.45 |
Day 2 | 0.06 (0.08) | 0.11 (0.14) | 0.13 |
Day 3 | 0.1 (0.14) | 0.08 (0.09) | 0.64 |
Serum NGAL | Â | Â | Â |
Pre-op | 82 (30) | 99 (54) | 0.43 |
Day 1 | 214 (91) | 259 (90) | 0.20 |
Day 2 | 213 (123) | 236 (123) | 0.54 |
Day 3 | 162 (68) | 224 (132) | 0.17 |
Day 4 | 102 (54) | 184 (133) | 0.04 |
Day 5 | 87 (31) | 147 (86) | 0.09 |
Serum BNP | Â | Â | Â |
Pre-op | 152 (94) | 194 (226) | 0.67 |
Day 1 | 111 (118) | 112 (118) | 0.67 |
Day 2 | 297 (202) | 337 (224) | 0.50 |
Day 3 | 364 (180) | 373 (219) | 0.76 |
Day 4 | 525 (151) | 442 (297) | 0.11 |
Day 5 | 458 (209) | 431 (208) | 0.67 |
Serum Creatinine | Â | Â | Â |
Pre-op | 0.99 (0.32) | 1.14 (0.39) | 0.31 |
Day 1 | 1.15 (0.45) | 1.32 (0.46) | 0.26 |
Day 2 | 1.53 (0.56) | 1.68 (0.67) | 0.5 |
Day 3 | 1.39 (0.57) | 2.06 (0.72) | <0.01 |
Day 4 | 1.21 (0.4) | 1.88 (0.67) | <0.01 |
Day 5 | 1.1 (0.33) | 1.66 (0.58) | <0.01 |
Serum Cystatin C | Â | Â | Â |
Pre-op | 0.92 (0.29) | 1.13 (0.4) | 0.13 |
Day 1 | 0.86 (0.27) | 1.02 (0.31) | 0.12 |
Day 2 | 1.04 (0.47) | 1.26 (0.43) | 0.11 |
Day 3 | 1.08 (0.34) | 1.54 (0.52) | <0.01 |
Day 4 | 0.99 (0.26) | 1.62 (0.52) | <0.01 |
Day 5 | 1.02 (0.27) | 1.49 (0.51) | 0.01 |