Plasma uric acid level indicates tubular interstitial leisions at early stage of IgA nephropathy

BMC Nephrology

Table 3 Correlation among tubulointerstitial score and plasma uric acid concentration in different eGFR groups

	T Oxford score	Tadj_Ox	T Beijing score	Tadj_Bj	GFR
*The whole cohort (N = 623)*
GFR	−0.473	−0.425	−0.513	−0.451
p	<0.001	<0.001	<0.001	<0.001
PUA	0.262	0.257	0.284	0.261	−0.371
p	<0.001	<0.001	<0.001	<0.001	<0.001
*Subgroup with eGFR > =90 ml/min* / *1.73 m* ² *(N = 258)*
GFR	−0.082	0.031	−0.002	−0.031
p	0.187	0.625	0.979	0.618
PUA	0.102	0.052	0.133	0.162	−0.160
p	0.104	0.405	0.032	0.009	0.010
*Subgroup with eGFR < 90 ml/min* / *1.73 m* ² *(N = 365)*
GFR	−0.490	−0.503	−0.493	−0.378
p	<0.001	<0.001	<0.001	<0.001
PUA	0.234	0.240	0.243	0.199	−0.374
p	<0.001	<0.001	<0.001	<0.001	<0.001

Analyses were performed with Spearman's correlation in the whole cohort and the subgroup with different GFR. PUA: plasma uric acid. Tubular atrophy/ interstitial fibrosis was analyzed as Oxford score, Beijing score Tadj_Ox: all individuals were re-attributed into two groups, according to 25% interstitial fibrosis/tubular atrophy (Tadj_Ox0 < =25%, Tadj_Ox1 > 25%); Tadj_Bj: all individuals were re-attributed to 10% interstitial fibrosis/tubular atrophy (Tadj_Bj0 < 10%, Tadj_Bj1 >= 10%).

ISSN: 1471-2369