Non-inferiority of creatinine excretion rate to urinary L-FABP and NGAL as predictors of early renal allograft function

Table 2 Discriminant values of urine markers for allograft function

Predictive marker	N	Time post-transplant (h)	IGF	SGF and DGF	p^a	ROC AUC (95% C.I.)^b	Optimal threshold value (sensitivity, specificity)^c
Urine output (ml/h)	67	4	390 (20-950)	50 (0-325)	<0.001	0.87 (0.77-0.94)	325 (100%, 57%)
UCr excretion rate (mmol/h)^d	58	10	0.99 (0.02-2.18)	0.26 (0-0.72)	<0.001	0.9 (0.8-0.96)	0.56 (94%, 84%)
UCr excretion rate (mmol/h)^d	67	24	0.85 (0.03-1.85)	0.25 (0-0.88)	<0.001	0.9 (0.8-0.96)	0.46 (78%, 94%)
L-FABP (mg/mmol UCr)	65	48	7.1 (0.1-53.5)	20 (4.7-75.2)	<0.001	0.85 (0.74-0.92)	9.5 (86%, 80%)
NGAL (μg/mmol UCr)	60	24	8.7 (0.2 – 107.1)	62.6 (1.8-770.9)	<0.001	0.82 (0.7-0.91)	33.1 (68%, 93%)

The discriminatory values of urine output, UCr excretion rate, L-FABP and NGAL are shown for early allograft function - the distinction between IGF and SGF/DGF groups.
^aMann-Whitney’s U test for difference between the groups.
^bThe differences between AUC for urine output, UCr at 10 h, L-FABP and NGAL were not statistically significant.
^cfor prediction of SGF/DGF; for urine output and UCr values below the optimal threshold value, for L-FABP and NGAL values above the threshold value.
^dUCr - urinary creatinine.

ISSN: 1471-2369