Associations of GSTM1*0 and GSTA1*Agenotypes with the risk of cardiovascular death among hemodialyses patients

Table 3 GSTA1 polymorphism (rs3957357) as a predictor for overall and cardiovascular mortality as well as death of myocardial infarction and cerebral vascular insult among 199 ESRD patients after a median follow-up time of 8 yrs by Cox proportional hazards regression models

Model 1^a		Model 2^b		Model 3^c
HR (95% CI)	P value	HR (95% CI)	P value	HR (95% CI)	P value
Risk for overall mortality comparing **GSTA1A* homozygotes to GSTA1B* carriers**
1.18 (0.68-2.07)	0.556	1.15 (0.65-2.02)	0.635	1.15 (0.64-2.07)	0.650
Risk for cardiovascular mortality comparing **GSTA1A* homozygotes to GSTA1B* carriers**
1.56 (0.80-3.04)	0.194	1.59 (0.81-3.11)	0.177	1.73 (0.84-3.55)	0.134
Risk for death from myocardial infarction comparing **GSTA1A* homozygotes to GSTA1B* carriers**
1.70 (0.68-4.29)	0.259	1.72 (0.68-4.36)	0.255	1.87 (0.68-5.15)	0.228
Risk for death from CVI comparing **GSTA1A* homozygotes to GSTA1B* carriers**
2.25 (0.81-6.21)	0.119	2.32 (0.83-6.46)	0.107	2.52 (0.86-7.36)	0.091

Abbreviations: CI Confidence Interval, HR Hazard Ratio, CVI Cerebral Vascular Insult.
^aAdjusted for age and gender.
^bAdjusted for the covariates in Model 1 plus an additional adjustment for smoking status.
^cAdjusted for the covariates in Model 2 plus an additional adjustment for diabetes and cholesterol level.

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