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Table 4 Combined effect of GSTM1/GSTA1 polymorphisms as predictors for overall and cardiovascular mortality as well as death of myocardial infarction and cerebral vascular insult among 199 ESRD patients after a median follow-up time of 8 yrs by Cox proportional hazards regression models

From: Associations of GSTM1*0 and GSTA1*Agenotypes with the risk of cardiovascular death among hemodialyses patients

Model 1a

Model 2b

Model 3c

HR (95% CI)

P value

HR (95% CI)

P value

HR (95% CI)

P value

Risk for overall mortality comparing combined GSTM1*0/0 and GSTA1*A/A homozygotes to carriers of at least one GSTM1 -active and/or GSTA1*B allele

1.86 (1.03-3.36)

0.039

1.98 (1.10-3.58)

0.023

2.08 (1.13-3.83)

0.019

Risk for cardiovascular mortality comparing combined GSTM1*0/0 and GSTA1*A/A homozygotes to carriers of at least one GSTM1- active and/or GSTA1*B allele

1.88 (0.93-3.82)

0.078

1.92 (0.95-3.91)

0.070

2.06 (0.98-4.34)

0.057

Risk for death of MI comparing combined GSTM1*0/0 and GSTA1*A/A homozygotes to carriers of at least one GSTM1- active and/or GSTA1*B allele

2.23 (0.86-5.80)

0.099

2.25 (0.86-5.89)

0.098

2.27 (0.81-6.38)

0.121

Risk for death of CVI comparing combined GSTM1*0/0 and GSTA1*A/A homozygotes to carriers of at least one GSTM1 active and/or GSTA1*B allele

3.35 (1.22-9.21)

0.019

3.55 (1.28-9.84)

0.015

4.38 (1.50-12.75)

0.007

  1. Abbreviations: CI Confidence Interval, HR Hazard Ratio, CVI Cerebral Vascular Insult, MI Myocardial Infarction.
  2. aAdjusted for age and gender.
  3. bAdjusted for the covariates in Model 1 plus an additional adjustment for smoking status.
  4. cAdjusted for the covariates in Model 2 plus an additional adjustment for diabetes and cholesterol level.