Model 1a | Model 2b | Model 3c | |||
---|---|---|---|---|---|
HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value |
Risk for overall mortality comparing combined GSTM1*0/0 and GSTA1*A/A homozygotes to carriers of at least one GSTM1 -active and/or GSTA1*B allele | |||||
1.86 (1.03-3.36) | 0.039 | 1.98 (1.10-3.58) | 0.023 | 2.08 (1.13-3.83) | 0.019 |
Risk for cardiovascular mortality comparing combined GSTM1*0/0 and GSTA1*A/A homozygotes to carriers of at least one GSTM1- active and/or GSTA1*B allele | |||||
1.88 (0.93-3.82) | 0.078 | 1.92 (0.95-3.91) | 0.070 | 2.06 (0.98-4.34) | 0.057 |
Risk for death of MI comparing combined GSTM1*0/0 and GSTA1*A/A homozygotes to carriers of at least one GSTM1- active and/or GSTA1*B allele | |||||
2.23 (0.86-5.80) | 0.099 | 2.25 (0.86-5.89) | 0.098 | 2.27 (0.81-6.38) | 0.121 |
Risk for death of CVI comparing combined GSTM1*0/0 and GSTA1*A/A homozygotes to carriers of at least one GSTM1 active and/or GSTA1*B allele | |||||
3.35 (1.22-9.21) | 0.019 | 3.55 (1.28-9.84) | 0.015 | 4.38 (1.50-12.75) | 0.007 |