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Figure 2 | BMC Nephrology

Figure 2

From: Injurious mechanical ventilation causes kidney apoptosis and dysfunction during sepsis but not after intra-tracheal acid instillation: an experimental study

Figure 2

Kidney apoptosis after mechanical ventilation. A and B show apoptotic indexes of renal cortex and medulla. Rats were ventilated for 4 hrs with different ventilatory strategies during sepsis or after intratracheal acid instillation. Healthy rats, rats subjected to sepsis or acid instillation alone served as controls. During sepsis apoptosis was increased compared to acid instillation. MV increased apoptosis and as indicated by an interaction between model and MV, MV with HVT increased apoptosis during sepsis, but not during acid instillation. C and D show representative photomicrographs of TUNEL stained apoptotic cells in renal cortex and medulla respectively (hematoxylin counterstain, magnification 400×). Apoptosis in cortex is most pronounced in endothelial cells after MV with HVT. LVT: mechanical ventilation with low tidal volume, HVT: mechanical ventilation with high tidal volume. *P < 0.001 compared to acid and control, #P < 0.001 compared to LVT sepsis and sepsis.

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