Figure 3
Rats were ventilated for 4 hrs with different ventilatory strategies during sepsis or after intratracheal acid instillation. Plasma creatinine levels were higher after acid instillation (n = 17) than after MV during sepsis (n = 20) (A). HVT decreased urine production as compared to LVT (B). Indicated by a significant interaction, HVT decreased creatinine clearance during sepsis (n = 20) but not after acid instillation (n = 17) (C). LVT: mechanical ventilation with low tidal volume, HVT: mechanical ventilation with high tidal volume. *P = 0.040 as comapred to sepsis, #P = 0.009 as compared to LVT, $P = 0.016 as compared to acid HVT.