Inclusion criteria | |||||||
---|---|---|---|---|---|---|---|
Study population | Cinacalcet | PTHa ≥ 500 ng/L | |||||
(N = 305) | (N = 44, 14.4%) | (N = 261, 85.6%) | |||||
Variables | N | N | N | p | |||
Ageb, years | 305 | 66.6 ± 15.3 | 44 | 63.3 ± 14.2 | 261 | 67.1 ± 15.4 | 0.122 |
Gender (males), % | 305 | 60 | 44 | 71 | 261 | 58 | 0.126 |
BMIc,b, kg/m2 | 301 | 28.6 ± 6.9 | 44 | 28.3 ± 6.3 | 257 | 28.7 ± 7.1 | 0.697 |
>30 kg/m2, % | 301 | 33.8 | 44 | 29.5 | 257 | 34.5 | 0.522 |
Type of dialysis, % | 304 | 44 | 261 | 0.340 | |||
Hemodialysis | 91.8 | 95.5 | 91.2 | ||||
Peritoneal dialysis | 8.2 | 4.5 | 8.8 | ||||
Dialysis vintageb, months | 305 | 27.5 ± 34.5 | 44 | 23.1 ± 24.5 | 261 | 28.3 ± 35.9 | 0.362 |
On transplant waiting list, % | 300 | 44 | 256 | 0.636 | |||
Yes | 8.3 | 11.4 | 7.9 | ||||
No | 91.7 | 88.6 | 92.1 | ||||
Primary etiology of nephropathy, % | 300 | 43 | 257 | 0.211 | |||
Diabetic nephropathy | 16.0 | 23.3 | 14.8 | ||||
Vascular nephropathy | 16.3 | 20.9 | 15.6 | ||||
Glomerulonephritis | 10 | 11.6 | 9.7 | ||||
Pyelonephritis | 4.7 | 7.0 | 4.3 | ||||
Hereditary nephropathy | 7.7 | 11.6 | 7.0 | ||||
Others/Unknown | 45.3 | 36.2 | 48.7 | ||||
Comorbidities, % | 305 | 44 | 261 | ||||
Cardiovascular diseases | 49.5 | 45.5 | 50.2 | 0.561 | |||
Diabetes | 44.9 | 31.8 | 47.1 | 0.590 | |||
Respiratory diseases | 11.5 | 15.9 | 10.7 | 0.319 | |||
Cancer | 13.1 | 6.8 | 14.2 | 0.181 | |||
Hypertension | 85.9 | 88.6 | 85.4 | 0.573 | |||
Smoking | 13.4 | 13.6 | 13.4 | 0.675 | |||
Clinical signs, % | 305 | 44 | 261 | ||||
Reported in medical records | 27.2 | 31.8 | 26.4 | 0.458 | |||
Reporded in PASd questionnaire | 44.9 | 31.8 | 47.1 | 0.059 | |||
Pain in the bones e | 125 | 17 | 12 | 6 | 110 | 21 | 0.317 |
Feeling tired easily e | 131 | 47 | 13 | 50 | 115 | 46 | 0.054 |
Mood swings e | 124 | 23 | 13 | 20 | 108 | 23 | 0.216 |
Feeling “blue” or depressed e | 123 | 6 | 12 | 6 | 108 | 6 | 0.184 |
Pain in the abdomen e | 124 | 12 | 11 | 4 | 110 | 13 | 0.055 |
Feeling weak e | 126 | 48 | 12 | 23 | 111 | 49 | 0.067 |
Feeling irritable e | 123 | 20 | 12 | 21 | 108 | 20 | 0.081 |
Pain in the joints e | 128 | 40 | 13 | 52 | 112 | 39 | 0.130 |
Forgetfulness e | 126 | 12 | 14 | 12 | 109 | 12 | 0.317 |
Difficulty to stand up e | 121 | 18 | 10 | 6 | 108 | 20 | 0.020 |
Headache e | 115 | 5 | 11 | 13 | 101 | 5 | 0.372 |
Dry skin e | 122 | 35 | 13 | 49 | 106 | 30 | 0.325 |
Being thirsty e | 121 | 51 | 13 | 51 | 105 | 51 | 0.265 |
Pruritus e | 122 | 20 | 12 | 49 | 107 | 16 | 0.302 |
Symptomatic patients, % | 122 | 58 | 12 | 52.3 | 107 | 59 | 0.402 |
Biological parameters | |||||||
PTHa,b, ng/L | 305 | 619 ± 226 | 44 | 468 ± 262 | 261 | 644 ± 210 | <0.0001 |
within KDIGO target f , % | 305 | 64.3 | 44 | 81.8 | 261 | 61.3 | 0.009 |
Serum calciumb, mg/L | 305 | 87.0 ± 7.1 | 44 | 81.8 ± 7.1 | 261 | 87.1 ± 7.2 | 0.681 |
Calcemia, % | 305 | 44 | 0.935 | ||||
≤ 84 mg/L | 42.6 | 43.2 | 42.5 | ||||
84-104 mg/L | 57.4 | 56.8 | 57.5 | ||||
> 104 mg/L | 0 | 0 | 261 | 0 | |||
Serum phosphorusb, mg/L | 305 | 54.4 ± 16.5 | 44 | 50.9 ± 17.6 | 261 | 55.0 ± 16.3 | 0.129 |
Phosphatemia, % | 305 | 44 | 0.675 | ||||
<25 mg/L | 2.6 | 2.3 | 2.7 | ||||
25-45 mg/L | 28.6 | 34.1 | 27.6 | ||||
>45 mg/L | 68.9 | 63.6 | 69.7 | ||||
Serum alkaline phosphataseb, UI/L | 299 | 103.4 ± 56.9 | 43 | 124.3 ± 97.0 | 256 | 99.9 ± 46.3 | 0.009 |
Bicarbonatemiab, mmol/L | 303 | 22.2 ± 3.4 | 44 | 22.4 ± 2.8 | 258 | 22.1 ± 3.5 | 0.618 |
Albuminb, g/L | 291 | 36.3 ± 4.6 | 42 | 36.7 ± 4.1 | 249 | 36.2 ± 4.6 | 0.504 |
Hemoglobinb, g/dL | 279 | 10.3 ± 1.6 | 44 | 10.6 ± 1.5 | 235 | 10.3 ± 1.6 | 0.245 |
Vitamin Db, ng/mL | 209 | 19.2 ± 13.5 | 31 | 15.8 ± 10.4 | 178 | 19.7 ± 13.9 | 0.138 |
Ionised calciumb, mmol/L | 58 | 1.1 ± 0.2 | 3 | 0.9 ± 0.8 | 55 | 1.1 ± 0.1 | 0.031 |
Treatment, % | 305 | 44 | 261 | ||||
Vitamin D (per os) | 63.9 | 72.7 | 62.5 | 0.189 | |||
Calcium | 68.9 | 81.8 | 66.7 | 0.045 | |||
Phosphorus binders | 59.3 | 61.4 | 59 0 | 0.768 | |||
Cinacalcet at inclusion | 14.4 | 100 | 0 | <0.0001 | |||
Cinacalcet at 3 months | 27.2 | 56.8 | 22.2 | <0.0001 |